INT336777

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ERAP2) endoplasmic reticulum (ERAP2)
Anatomy Link Frequency
reticulum 4
ERAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
spinal inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 18 97.04 Very High Very High Very High
Targeted Disruption 36 96.88 Very High Very High Very High
Epstein-barr Virus 6 67.84 Quite High
Lymphatic System Cancer 6 56.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 24 46.16 Quite Low
Eclampsia 36 5.00 Very Low Very Low Very Low
Malaria 24 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Reprotox - General 1 6 5.00 Very Low Very Low Very Low
Hypertension 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, several studies have previously identified associations between SNPs in this genomic region and changes in ERAP2 expression and splicing [40]–[43].
Regulation (changes) of Gene_expression (expression) of ERAP2
1) Confidence 0.61 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.07 Pain Relevance 0
Here, we present genetic and functional evidence that another gene with a fundamental role in MHC class I presentation, endoplasmic reticulum aminopeptidase 2 (ERAP2), has also evolved under balancing selection and contains a variant that affects antigen presentation.
Regulation (role) of Gene_expression (presentation) of ERAP2 in reticulum
2) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
In light of the differences in ERAP2 expression from the A versus B haplotypes, what are the biological consequences of lower ERAP2 protein levels in AB and BB individuals?
Regulation (differences) of Gene_expression (expression) of ERAP2
3) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.10 Pain Relevance 0
Effects of ERAP2 variants on MHC class I presentation
Regulation (Effects) of Gene_expression (variants) of ERAP2
4) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.15 Pain Relevance 0
Therefore, based on our results, the ERAP2 genotype should be accounted for in interpreting ERAP2 studies, especially those focused on ERAP2 expression and ERAP2 protein function.
Regulation (focused) of Gene_expression (expression) of ERAP2
5) Confidence 0.45 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.09 Pain Relevance 0
Here, we present genetic and functional evidence that another gene with a fundamental role in MHC class I presentation, endoplasmic reticulum aminopeptidase 2 (ERAP2), has also evolved under balancing selection and contains a variant that affects antigen presentation.
Regulation (role) of Gene_expression (presentation) of aminopeptidase 2 in reticulum
6) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0

General Comments

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