INT336926

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.57
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
lung 1
Mir341 (Mus musculus)
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 19 99.64 Very High Very High Very High
Inflammation 18 81.52 Quite High
corticosteroid 1 77.04 Quite High
Bioavailability 2 71.12 Quite High
Inflammatory response 6 70.76 Quite High
alcohol 5 25.00 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pseudomonas Infection 18 100.00 Very High Very High Very High
Cystic Fibrosis 19 99.64 Very High Very High Very High
Pulmonary Disease 21 99.52 Very High Very High Very High
Lung Cancer 1 91.68 High High
Asthma 2 91.16 High High
Hypersensitivity 1 90.84 High High
Disease 6 88.64 High High
INFLAMMATION 23 81.52 Quite High
Infection 1 72.68 Quite High
Toxicity 2 20.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test the efficacy of our novel therapeutic drug delivery vehicle we have tested the sustained release and delivery of FDA approved proteasome inhibitor drug, PS341 in murine lungs by its ability to control Pseudomonas aeruginosa LPS induced CF lung disease in murine model.
PS341 Regulation (control) of LPS in lung associated with fibrosis, pseudomonas infection and pulmonary disease
1) Confidence 0.02 Published 2010 Journal J Nanobiotechnology Section Body Doc Link PMC2954907 Disease Relevance 1.57 Pain Relevance 0.41

General Comments

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