INT336946

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.02
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA4, VCAM1) plasma membrane (ITGA4, VCAM1) extracellular space (VCAM1)
aging (VCAM1)
Anatomy Link Frequency
brain 1
ITGA4 (Homo sapiens)
VCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 15 87.28 High High
Multiple sclerosis 54 50.00 Quite Low
Neuronal excitability 1 29.52 Quite Low
cytokine 5 27.84 Quite Low
gABA 1 23.12 Low Low
Glutamate 1 22.76 Low Low
Neurotransmitter 1 22.04 Low Low
antiepileptic Drug 9 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
carbamazepine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 55 99.38 Very High Very High Very High
Chronic Disease 1 94.88 High High
Adhesions 12 94.40 High High
Vasculitis 5 88.00 High High
INFLAMMATION 11 86.60 High High
Epilepsy 66 83.04 Quite High
Infection 2 80.56 Quite High
Autoimmune Disease 2 79.44 Quite High
Disease 16 61.04 Quite High
Demyelinating Disease 55 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, it has been recently shown that also recurrent seizures lead to chronic expression of VCAM-1, the ligand for VLA-4 integrin, potentially contributing to BBB permeability, neuroinflammation and brain damage potentially contributing to the evolution of chronic disease [10].
VLA-4 integrin Binding (ligand) of VCAM-1 in brain associated with convulsion and chronic disease
1) Confidence 0.03 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2954970 Disease Relevance 2.02 Pain Relevance 0.21

General Comments

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