INT33706

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Context Info
Confidence 0.28
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.46
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
reticulum 1
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 18 99.96 Very High Very High Very High
Potency 3 93.84 High High
agonist 90 91.84 High High
Glutamate 43 67.68 Quite High
long-term potentiation 1 62.08 Quite High
Morphine 1 49.12 Quite Low
opiate 1 48.08 Quite Low
Pain 6 43.00 Quite Low
Glutamate receptor 12 37.92 Quite Low
qutenza 1 37.32 Quite Low
Disease Link Frequency Relevance Heat
Vibrio Infection 2 99.22 Very High Very High Very High
Bordatella Infection 4 94.64 High High
Cancer 1 87.28 High High
Stress 2 58.52 Quite High
Pain 6 43.00 Quite Low
Targeted Disruption 2 37.92 Quite Low
Nociception 1 22.36 Low Low
Arterial-venous Cerebral Malformations 1 16.60 Low Low
Overactive Bladder 23 5.00 Very Low Very Low Very Low
Helminth Infection 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested for the possible involvement of the IP3 receptor in the Echinacea-induction of intracellular Ca2+ release by evaluating the effect of 2-aminoethoxydiphenyl borate (2-APB), an IP3 receptor antagonist, on Echinacea-induced cytosolic Ca2+ increase.
Regulation (effect) of IP3 receptor associated with antagonist
1) Confidence 0.28 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.05
We used a dominant-negative construct (IP3 sponge), as well as loss-of-function mutants and RNA interference, to demonstrate that IP3 signalling and IP3Rs function in the regulation of pharyngeal pumping rate and in multiple stages of embryogenesis [20].
Regulation (regulation) of IP3Rs
2) Confidence 0.10 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2729924 Disease Relevance 0 Pain Relevance 0
In addition, caffeine also acts on the other primary endoplasmic reticulum calcium release channel, the inositol triphosphate receptor (IP3R), over the same concentration range.
Regulation (acts) of IP3R in reticulum
3) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2525814 Disease Relevance 0 Pain Relevance 0.06
following its secondary restimulation (Fig. 2G, p = 0.0049), it had no significant effect on IP3 generation by TP?
Neg (no) Regulation (effect) of IP3
4) Confidence 0.02 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.06 Pain Relevance 0.14
It was demonstrated that tetracaine and ryanodine could reduce IP3-mediated Ca2+ signals by directly affecting IP3 receptors or depleting the (shared) store of Ca2+, respectively.
Regulation (affecting) of IP3
5) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2640952 Disease Relevance 0 Pain Relevance 0
Pretreatment of the cells with cholera toxin (30 nM for 24 h) also failed to affect basal or TRH-stimulated IP3 formation.
Neg (failed) Regulation (affect) of IP3 associated with vibrio infection
6) Confidence 0.01 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 3013886 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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