INT337085

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.89
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) endosome (Cxcr4) cytoplasm (Mif)
signal transducer activity (Cxcr4) cell proliferation (Mif) signal transduction (Cxcr4)
Anatomy Link Frequency
macrophage 1
Cxcr4 (Mus musculus)
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
cva 1 99.22 Very High Very High Very High
chemokine 1 99.20 Very High Very High Very High
rheumatoid arthritis 1 77.52 Quite High
Inflammation 20 71.44 Quite High
fibrosis 1 71.00 Quite High
cINOD 1 41.84 Quite Low
cytokine 8 33.48 Quite Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 99.96 Very High Very High Very High
Cv General 3 Under Development 1 99.22 Very High Very High Very High
Reprotox - General 1 3 96.80 Very High Very High Very High
Disease 10 94.56 High High
Malignant Neoplastic Disease 2 94.38 High High
Rheumatoid Arthritis 1 77.52 Quite High
Injury 2 76.64 Quite High
INFLAMMATION 23 71.44 Quite High
Cystic Fibrosis 1 71.00 Quite High
Cancer 41 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The higher levels of MIF associated with this particular variant also correlated with progressive disease.16 In relation to malignant diseases, individuals carrying the seven-repeat allele were also found to have an increased incidence of prostate cancer.17 MIF biological activity has also been implicated in the pathogenesis of atherosclerosis and abdominal aortic aneurysm.18 In the context of atherosclerosis, MIF has also been identified as a non-cognate receptor of CXCR2 and CXCR4 and has functional chemokine activity in evolving atherosclerosis mediating monocyte arrest and the formation of plaques.19 Additionally, as part of this disease process MIF can induce the CXCR ligand, Interleukin (IL)-8 and regulators of macrophage infiltration ICAM-1 and CD44, confirming its relevance in this disease.20
CXCR4 Binding (receptor) of MIF in macrophage associated with chemokine, malignant neoplastic disease, cva, increased venous pressure under development, disease and reprotox - general 1
1) Confidence 0.21 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.89 Pain Relevance 0.30

General Comments

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