INT337103

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rps6ka5) kinase activity (Rps6ka5) response to stress (Rps6ka5)
cytoplasm (Rps6ka5)
Anatomy Link Frequency
nucleus 4
Rps6ka5 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 18 95.72 Very High Very High Very High
cocaine 10 95.32 Very High Very High Very High
Dopamine 42 90.40 High High
antagonist 4 22.88 Low Low
Enkephalin 10 5.00 Very Low Very Low Very Low
substance P 10 5.00 Very Low Very Low Very Low
GABAergic 8 5.00 Very Low Very Low Very Low
Dynorphin 6 5.00 Very Low Very Low Very Low
projection neuron 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 100.00 Very High Very High Very High
Targeted Disruption 24 68.04 Quite High
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ERK activation induces the phosphorylation in the nucleus of mitogen- and stress-activated kinase-1 (MSK1) and histone H3, responses that are also restricted to D1R-expressing MSNs of the dorsal striatum and the NAc after cocaine (Bertran-Gonzalez et al., 2008).
Positive_regulation (induces) of Phosphorylation (phosphorylation) of stress-activated kinase-1 in nucleus associated with stress, nucleus accumbens and cocaine
1) Confidence 0.33 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.17 Pain Relevance 0.30
ERK activation induces the phosphorylation in the nucleus of mitogen- and stress-activated kinase-1 (MSK1) and histone H3, responses that are also restricted to D1R-expressing MSNs of the dorsal striatum and the NAc after cocaine (Bertran-Gonzalez et al., 2008).
Positive_regulation (induces) of Phosphorylation (phosphorylation) of MSK1 in nucleus associated with stress, nucleus accumbens and cocaine
2) Confidence 0.33 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.17 Pain Relevance 0.30

General Comments

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