INT337112

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
striatum 2
Nr1d2-rs2 (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 9 91.76 High High
antagonist 2 87.20 High High
Dopamine 21 80.72 Quite High
cocaine 5 75.64 Quite High
Enkephalin 5 5.00 Very Low Very Low Very Low
substance P 5 5.00 Very Low Very Low Very Low
GABAergic 4 5.00 Very Low Very Low Very Low
Dynorphin 3 5.00 Very Low Very Low Very Low
projection neuron 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 70.72 Quite High
Stress 1 69.68 Quite High
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of ERK activation in neurons expressing D2R may result from a negative effect of D2R on ERK activation, since pharmacological blockade of D2Rs by haloperidol or raclopride selectively activates ERK and induces histone H3 phosphorylation in D2R-expressing striatopallidal MSNs in the dorsal striatum (Bertran-Gonzalez et al., 2008, 2009).
Negative_regulation (blockade) of D2Rs in striatum Positive_regulation (activates) of ERK
1) Confidence 0.00 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.14 Pain Relevance 0.33

General Comments

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