INT33713

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Context Info
Confidence 0.00
First Reported 1986
Last Reported 1986
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ITPR3, Trh) nucleus (ITPR3, Trh) nucleoplasm (ITPR3)
small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3) transmembrane transport (ITPR3)
ITPR3 (Homo sapiens)
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 4 99.16 Very High Very High Very High
Morphine 2 63.60 Quite High
opiate 2 62.56 Quite High
agonist 2 62.00 Quite High
Disease Link Frequency Relevance Heat
Vibrio Infection 4 96.60 Very High Very High Very High
Bordatella Infection 8 92.80 High High
Cancer 2 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRH was also able to stimulate IP3 formation with a half-maximal potency of 118 +/- 10 nM in a lysed cell preparation of 7315c cells; the TRH-stimulated formation of IP3 was enhanced by GTP. 5'-Guanosine gamma-thiotriphosphate (GTP gamma S) and 5'-guanylyl imidodiphosphate (Gpp(NH)p), nonhydrolyzable analogs of GTP, stimulated IP3 formation in the absence of TRH with half-maximal potencies of 162 +/- 50 and 7500 +/- 4300 nM, respectively.
IP3 Binding (formation) of TRH associated with potency
1) Confidence 0.00 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 3013886 Disease Relevance 0.46 Pain Relevance 0.21
TRH was also able to stimulate IP3 formation with a half-maximal potency of 118 +/- 10 nM in a lysed cell preparation of 7315c cells; the TRH-stimulated formation of IP3 was enhanced by GTP. 5'-Guanosine gamma-thiotriphosphate (GTP gamma S) and 5'-guanylyl imidodiphosphate (Gpp(NH)p), nonhydrolyzable analogs of GTP, stimulated IP3 formation in the absence of TRH with half-maximal potencies of 162 +/- 50 and 7500 +/- 4300 nM, respectively.
IP3 Binding (formation) of TRH associated with potency
2) Confidence 0.00 Published 1986 Journal J. Biol. Chem. Section Abstract Doc Link 3013886 Disease Relevance 0.40 Pain Relevance 0.18

General Comments

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