INT337151

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 3.69
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Iqgap1) nucleus (Iqgap1) protein complex (Iqgap1)
cytoplasm (Iqgap1)
Anatomy Link Frequency
macrophages 4
hindlimb 4
blood 2
femoral artery 2
capillary 2
Iqgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 264 99.98 Very High Very High Very High
Inflammation 240 89.92 High High
fibrosis 24 84.48 Quite High
Inflammatory response 8 54.44 Quite High
chemokine 8 45.56 Quite Low
cytokine 24 26.20 Quite Low
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 264 99.98 Very High Very High Very High
Vasculitis 8 98.48 Very High Very High Very High
Injury 48 97.52 Very High Very High Very High
Cancer 24 94.08 High High
Necrosis 88 91.76 High High
INFLAMMATION 248 89.92 High High
Adhesions 88 87.04 High High
Fibrosis 24 84.48 Quite High
Disease 16 60.40 Quite High
Pressure And Volume Under Development 8 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we found that IQGAP1 expression is dramatically increased in the regenerating ECs layers after vascular injury [18] as well as in capillary-like ECs during angiogenesis after hindlimb ischemia [21].
Positive_regulation (increased) of Gene_expression (expression) of IQGAP1 in capillary associated with ischemia and vasculitis
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.38 Pain Relevance 0.07
Western analysis showed that IQGAP1 protein expression was increased in ischemic muscles at days 3 and 7 after hindlimb ischemia (Figure 2A).
Positive_regulation (was incre) of Gene_expression (ein expres) of IQGAP1 protein in hindlimb associated with ischemia
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.79 Pain Relevance 0.26
Here we show that: 1) Hindlimb ischemia increases IQGAP1 expression in infiltrating macrophages and ECs in ischemic tissues; 2) Mice lacking IQGAP1 show decreased blood flow recovery, capillary density and ?
Positive_regulation (increases) of Gene_expression (expression) of IQGAP1 in blood associated with ischemia
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.27 Pain Relevance 0.05
Western analysis confirmed that IQGAP1 is abundantly expressed in BMCs, which is further upregulated by contra lateral hindlimb ischemia (Figure 6A).
Positive_regulation (upregulated) of Gene_expression (expressed) of IQGAP1 in hindlimb associated with ischemia
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.59 Pain Relevance 0.26
The present study also demonstrates that IQGAP1 expression is increased in ischemic tissues, which may be due to increased, infiltrated macrophages and newly formed ECs, which express IQGAP1, at day 3 and 7, respectively.
Positive_regulation (increased) of Gene_expression (expression) of IQGAP1 in macrophages
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.32 Pain Relevance 0.13
In the present study, we demonstrate that IQGAP1 expression is increased in infiltrated macrophages and ECs in ischemic tissues.
Positive_regulation (increased) of Gene_expression (expression) of IQGAP1 in macrophages
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.32 Pain Relevance 0.07
Ischemia was induced by left femoral artery ligation, which resulted in increased IQGAP1 expression in Mac3+ macrophages and CD31+ capillary-like ECs in ischemic legs.
Positive_regulation (increased) of Gene_expression (expression) of IQGAP1 in femoral artery associated with ischemia
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955540 Disease Relevance 0.45 Pain Relevance 0.12
We also reported that IQGAP1 expression is upregulated in regenerating ECs in response to vascular [18] or ischemic injury [21].
Positive_regulation (upregulated) of Gene_expression (expression) of IQGAP1 associated with injury
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.57 Pain Relevance 0.19

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