INT337157

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.91
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Iqgap1, Ros1) cell differentiation (Ros1) protein complex (Iqgap1)
cytoplasm (Iqgap1) cell proliferation (Ros1) signal transduction (Ros1)
Anatomy Link Frequency
Macrophage 4
hindlimb 2
Iqgap1 (Mus musculus)
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 99 99.16 Very High Very High Very High
Inflammation 90 91.84 High High
fibrosis 9 75.16 Quite High
cytokine 9 60.64 Quite High
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 99 99.16 Very High Very High Very High
Peritonitis 15 98.88 Very High Very High Very High
Adhesions 33 94.56 High High
INFLAMMATION 93 91.84 High High
Necrosis 33 86.08 High High
Targeted Disruption 3 79.44 Quite High
Fibrosis 9 75.16 Quite High
Fibromyalgia 3 67.48 Quite High
Injury 18 35.68 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since IQGAP1 is expressed in both macrophages and capillary-like ECs (Figure 2), which are major sources of ROS in ischemic tissue [11], we next examined the role of IQGAP1 in ROS production induced by hindlimb ischemia.
IQGAP1 Spec (examined) Regulation (role) of Gene_expression (production) of ROS in hindlimb associated with ischemia
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.79 Pain Relevance 0.42
IQGAP1 plays a key role in post-ischemic neovascularization by regulating, not only, ECs-mediated angiogenesis but also macrophage infiltration as well as ROS production.
IQGAP1 Regulation (regulating) of Gene_expression (production) of ROS in macrophage
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955540 Disease Relevance 0.38 Pain Relevance 0.06
IQGAP1 is involved in Macrophage Recruitment and ROS production in Thioglycollate-elicited Peritonitis Model
IQGAP1 Regulation (involved) of Gene_expression (production) of ROS in Macrophage associated with peritonitis
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955540 Disease Relevance 0.73 Pain Relevance 0.23

General Comments

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