INT33717

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Context Info
Confidence 0.54
First Reported 1981
Last Reported 1996
Negated 6
Speculated 3
Reported most in Abstract
Documents 15
Total Number 18
Disease Relevance 3.30
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adh1) mitochondrion (Adh1) oxidoreductase activity (Adh1)
intracellular (Adh1) embryo development (Adh1) cytoplasm (Adh1)
Anatomy Link Frequency
cardiovascular system 8
plasma 6
brain 4
ventricles 3
neurons 3
Adh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 24 100.00 Very High Very High Very High
antagonist 8 99.18 Very High Very High Very High
Clonidine 12 97.32 Very High Very High Very High
anesthesia 1 91.00 High High
Pain 1 81.92 Quite High
medulla 2 66.68 Quite High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 16 98.00 Very High Very High Very High
Pressure And Volume Under Development 6 98.00 Very High Very High Very High
Heart Rate Under Development 8 97.36 Very High Very High Very High
Sleep Disorders 10 91.44 High High
Pain 1 81.92 Quite High
Cv Unclassified Under Development 4 81.60 Quite High
Stress 1 81.28 Quite High
Bradycardia 4 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to investigate the role of central noradrenergic neurons in the control of vasopressin (ADH) release and cardiovascular regulation, norepinephrine (1.4 microgram/kg), clonidine (0.1 microgram/kg), and isoproterenol (1.4 microgram/kg were infused into the lateral cerebral ventricle of the anesthetized dog.
Spec (investigate) Regulation (role) of in ventricle Localization (release) of ADH in neurons associated with clonidine
1) Confidence 0.54 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.06 Pain Relevance 0.17
Effect of postoperative extradural morphine on ADH secretion.
Regulation (Effect) of Localization (secretion) of ADH associated with morphine
2) Confidence 0.50 Published 1985 Journal Br J Anaesth Section Title Doc Link 3986069 Disease Relevance 0 Pain Relevance 0.62
Volume receptors are situated in many organs and are capable of modulating ADH secretion.
Regulation (modulating) of Localization (secretion) of ADH
3) Confidence 0.44 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8884540 Disease Relevance 0.16 Pain Relevance 0.08
The effect of extradural morphine on antidiuretic hormone (ADH) secretion was assessed for the first 6 h after surgery in three groups of patients.
Regulation (effect) of Localization (secretion) of ADH associated with morphine
4) Confidence 0.37 Published 1985 Journal Br J Anaesth Section Abstract Doc Link 3986069 Disease Relevance 0 Pain Relevance 0.38
In order to investigate the role of central alpha 1- and alpha 2-adrenoceptors in the control of vasopressin (ADH) release and the cardiovascular system, norepinephrine (NE) (1.4 microgram/kg), methoxamine (1.4 microgram/kg), yohimbine (60 micrograms/kg), and prazosin (40 micrograms/kg) were administered via the cerebral ventricles in urethane-chloralose-anesthetized dogs after morphine sedation (n = 42).
Regulation (control) of Localization (release) of ADH in ventricles associated with sleep disorders and morphine
5) Confidence 0.37 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.22 Pain Relevance 0.09
In order to investigate the role of central noradrenergic neurons in the control of vasopressin (ADH) release and cardiovascular regulation, norepinephrine (1.4 microgram/kg), clonidine (0.1 microgram/kg), and isoproterenol (1.4 microgram/kg were infused into the lateral cerebral ventricle of the anesthetized dog.
Regulation (control) of Localization (release) of ADH in neurons associated with clonidine
6) Confidence 0.24 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.06 Pain Relevance 0.17
Isoproterenol had no effect on ADH release and produced a slight reduction in arterial pressure and a large increase in heart rate.
Neg (no) Regulation (effect) of Localization (release) of ADH in heart associated with heart rate under development
7) Confidence 0.24 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.17 Pain Relevance 0.18
In none of the experiments could changes in ADH release be attributed to changes in plasma osmolality or plasma sodium and potassium concentrations.
Regulation (changes) of Localization (release) of ADH in plasma
8) Confidence 0.24 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.18 Pain Relevance 0.23
These results indicate that central alpha 1-adrenoceptors might act to activate the cardiovascular system, but have no effects on ADH release in anesthetized dogs.
Neg (no) Regulation (effects) of Localization (release) of ADH in cardiovascular system
9) Confidence 0.16 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.30 Pain Relevance 0.06
In none of the experiments could changes in ADH release be attributed to changes in plasma osmolality.
Regulation (changes) of Localization (release) of ADH in plasma
10) Confidence 0.16 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.33 Pain Relevance 0.07
Pretreatment with prazosin did not block significantly the effect of NE on blood pressure, heart rate, and ADH release.
Regulation (effect) of Localization (release) of ADH in blood
11) Confidence 0.16 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.35 Pain Relevance 0.08
Yohimbine did not affect the cardiovascular system and ADH release significantly.
Neg (not) Regulation (affect) of Localization (release) of ADH in cardiovascular system
12) Confidence 0.16 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.35 Pain Relevance 0.08
Methoxamine tended to activate the cardiovascular system, but did not affect the release of ADH significantly.
Neg (not) Regulation (affect) of Localization (release) of ADH in cardiovascular system
13) Confidence 0.16 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.35 Pain Relevance 0.09
Ang II antagonist given intracerebroventricularly neither affected ADH release and the cardiovascular system in 0.15 M NaCl nor inhibited ADH release in response to osmotic stimulation.
Neg (neither) Regulation (affected) of Localization (release) of ADH in cardiovascular system associated with antagonist
14) Confidence 0.08 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3014365 Disease Relevance 0.29 Pain Relevance 0.10
In order to investigate the physiological role of the brain renin-angiotensin system in the regulation of vasopressin (ADH) release, angiotensin II (Ang II, 10 ng/kg/min) or 1-Sar-8-Ile-Ang II (50 ng/kg/min), an Ang II antagonist, was administered intracerebroventricularly to dogs (n = 42) anesthetized with urethane and chloralose after morphine sedation.
Spec (investigate) Regulation (role) of Localization (release) of ADH in brain associated with antagonist, sleep disorders and morphine
15) Confidence 0.07 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3014365 Disease Relevance 0.09 Pain Relevance 0.14
ACSF given intracerebroventricularly plus 0.15 M NaCl given intravenously did not affect ADH release, but 2.5 M NaCl given intravenously raised the plasma ADH level in parallel with the rise in plasma osmolality.
Neg (not) Regulation (affect) of Localization (release) of ADH in plasma
16) Confidence 0.06 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3014365 Disease Relevance 0.31 Pain Relevance 0.13
In order to investigate the physiological role of the brain renin-angiotensin system in the regulation of vasopressin (ADH) release, angiotensin II (Ang II, 10 ng/kg/min) or 1-Sar-8-Ile-Ang II (50 ng/kg/min), an Ang II antagonist, was administered intracerebroventricularly to dogs (n = 42) anesthetized with urethane and chloralose after morphine sedation.
Regulation (regulation) of Localization (release) of ADH in brain associated with antagonist, sleep disorders and morphine
17) Confidence 0.03 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3014365 Disease Relevance 0.09 Pain Relevance 0.14
In a second series of experiments, ANG II was infused in 0.1 and 1.0 M NaCl (200 ng X kg-1 X min-1) to examine the effect of the peptide on osmotic release of ADH.
Spec (examine) Regulation (effect) of Localization (release) of ADH
18) Confidence 0.01 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3740316 Disease Relevance 0 Pain Relevance 0.09

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