INT337264

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F1) mitochondrion (E2F1) DNA binding (E2F1)
cytoplasm (E2F1) cell proliferation (E2F1) extracellular space (THBS1)
Anatomy Link Frequency
covering 1
E2F1 (Homo sapiens)
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Gabapentin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 75 92.88 High High
Metastasis 15 72.56 Quite High
Wound Healing 10 5.00 Very Low Very Low Very Low
Repression 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Foreign-body Reaction 5 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Leukemia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, E2F-1 could also directly bind to the TSP1 promoter region covering ?
E2F-1 Binding (bind) of TSP1 in covering
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955548 Disease Relevance 0.14 Pain Relevance 0
These results indicated that E2F1 could bind to the TSP1 promoter directly in 293 cells.


E2F1 Binding (bind) of TSP1
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
To demonstrate whether the action of E2F1 on TSP1 occurs in vivo, we conducted chromatin Immunoprecipitation assay to test the binding of E2F1 in the TSP1 promoter.
E2F1 Binding (binding) of TSP1
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Here, we presented data to show that pRB1 could also suppress E2F-1's transactivity on TSP1 promoter in a dose-dependent manner, which is consistent with the role of pRB1 in modulating expression of E2F-1 targets, further confirming that TSP1 serves as a bona fide target of E2F-1.
E2F-1 Binding (target) of TSP1
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.64 Pain Relevance 0
E2F1 binds to the TSP1 promoter in vivo
E2F1 Binding (binds) of TSP1
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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