INT337266

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F1) mitochondrion (E2F1) DNA binding (E2F1)
cytoplasm (E2F1) cell proliferation (E2F1) extracellular space (THBS1)
E2F1 (Homo sapiens)
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 40.20 Quite Low
Gabapentin 2 35.48 Quite Low
Inflammation 2 19.08 Low Low
ischemia 2 16.44 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 30 78.92 Quite High
Leukemia 2 63.36 Quite High
Wound Healing 4 44.16 Quite Low
INFLAMMATION 2 19.08 Low Low
Foreign-body Reaction 2 18.08 Low Low
Cv Unclassified Under Development 2 16.44 Low Low
Apoptosis 2 11.44 Low Low
Metastasis 6 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using promoter assays, Northern blot and ChIP (chromatin immunoprecipitation) assays, we identified that E2F-1 could directly transactivate TSP1 expression by binding to its promoter, further expending TSP1's regulatory factors.


E2F-1 Positive_regulation (transactivate) of Gene_expression (expression) of TSP1
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.21 Pain Relevance 0
We next want to test whether E2F1 could up-regulate expression of the endogenous TSP1 gene.
E2F1 Positive_regulation (up-regulate) of Gene_expression (expression) of TSP1 gene
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox