INT337272

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 1.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (E2F1) mitochondrion (E2F1) DNA binding (E2F1)
cytoplasm (E2F1) cell proliferation (E2F1) extracellular space (THBS1)
E2F1 (Homo sapiens)
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 9 49.52 Quite Low
Gabapentin 9 44.80 Quite Low
Inflammation 9 28.40 Quite Low
ischemia 9 25.76 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 135 95.84 Very High Very High Very High
Repression 9 75.64 Quite High
Leukemia 9 72.68 Quite High
Wound Healing 18 53.48 Quite High
Metastasis 27 50.24 Quite High
INFLAMMATION 9 28.40 Quite Low
Foreign-body Reaction 9 27.40 Quite Low
Cv Unclassified Under Development 9 25.76 Quite Low
Apoptosis 9 20.76 Low Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we presented data to show that pRB1 could also suppress E2F-1's transactivity on TSP1 promoter in a dose-dependent manner, which is consistent with the role of pRB1 in modulating expression of E2F-1 targets, further confirming that TSP1 serves as a bona fide target of E2F-1.
E2F-1 Positive_regulation (transactivity) of TSP1
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.60 Pain Relevance 0
These results not only further confirmed the up-regulation of TSP-1 by E2F-1 effectively, but also ruled out the non-specific up-regulation of TSP-1 promoter activity as a result of ectopic expression of large amount of E2F-1 expression vector.
E2F-1 Positive_regulation (up-regulation) of TSP-1
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.08 Pain Relevance 0
In this study, we found that E2F-1 could transactivate TSP1 promoter activity and TSP1 promoter region contains potential E2F-1 binding consensus sequences.
E2F-1 Positive_regulation (transactivate) of TSP1
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.30 Pain Relevance 0
The luciferase assays showed that VP16-E2F1-(110–194) could indeed transactivate the TSP1 promoter reporters significantly (p<0.0001) but not TSP1 (?
E2F1 Neg (not) Positive_regulation (transactivate) of TSP1
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
When the three putative binding sites were mutated simultaneously, the transactivation of TSP1 induced by E2F1 was abolished completely.
E2F1 Positive_regulation (induced) of TSP1
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
In this study, we found that E2F-1 could transactivate TSP1 promoter activity and TSP1 promoter region contains potential E2F-1 binding consensus sequences.
E2F-1 Positive_regulation (transactivate) of TSP1
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.30 Pain Relevance 0
The luciferase assays showed that VP16-E2F1-(110–194) could indeed transactivate the TSP1 promoter reporters significantly (p<0.0001) but not TSP1 (?
E2F1 Neg (not) Positive_regulation (transactivate) of TSP1
7) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Up-regulation of TSP1 mRNA by E2F1 was confirmed by Northern blot analysis (Fig. 4) which suggested that E2F1 could indeed induce TSP1 mRNA expression.


E2F1 Positive_regulation (Up-regulation) of TSP1
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
When the three putative binding sites were mutated simultaneously, the transactivation of TSP1 induced by E2F1 was abolished completely.
E2F1 Positive_regulation (transactivation) of TSP1
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0

General Comments

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