INT337293

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTAFR, TLR4) signal transduction (TLR4) nucleolus (PTAFR)
intracellular (TLR4) nucleus (PTAFR) cytoplasm (TLR4)
Anatomy Link Frequency
intestinal epithelium 2
Platelet 2
PTAFR (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 99.88 Very High Very High Very High
Inflammation 28 99.48 Very High Very High Very High
Inflammatory mediators 2 98.88 Very High Very High Very High
Inflammatory response 4 96.04 Very High Very High Very High
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 20 100.00 Very High Very High Very High
Hypoxia 4 100.00 Very High Very High Very High
Infection 2 100.00 Very High Very High Very High
INFLAMMATION 28 99.48 Very High Very High Very High
Necrosis 2 94.24 High High
Neonatal Necrotizing Enterocolitis 68 93.72 High High
Adhesions 2 58.72 Quite High
Increased Venous Pressure Under Development 4 55.52 Quite High
Apoptosis 6 44.92 Quite Low
Endotoxemia 2 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet-activating factor induces TLR4 promoter activation
Platelet-activating factor Positive_regulation (induces) of Positive_regulation (activation) of TLR4 in Platelet
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.10 Pain Relevance 0.10
We hypothesized that PAF, which is released due to hypoxia, infection, or local injury, induces an upregulation of TLR4 at the intestinal epithelium that predisposes to excessive bacterial activation of the intestinal inflammatory response, leading to intestinal necrosis and NEC.
PAF Positive_regulation (induces) of Positive_regulation (upregulation) of TLR4 in intestinal epithelium associated with neonatal necrotizing enterocolitis, necrosis, inflammatory response, hypoxia, injury and infection
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.33 Pain Relevance 0.18

General Comments

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