INT337295

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (PTAFR, STAT3) nucleolus (PTAFR, STAT3) nucleus (PTAFR, STAT3)
plasma membrane (PTAFR, STAT3) nucleoplasm (STAT3) DNA binding (STAT3)
Anatomy Link Frequency
enterocytes 2
epithelial cells 2
PTAFR (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 28 88.68 High High
Inflammatory response 4 78.04 Quite High
Inflammatory mediators 2 68.20 Quite High
cytokine 6 67.44 Quite High
anesthesia 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Crohn's disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 28 88.68 High High
Neonatal Necrotizing Enterocolitis 68 79.64 Quite High
Necrosis 2 79.32 Quite High
Injury 20 71.92 Quite High
Infection 2 71.24 Quite High
Hypoxia 4 70.80 Quite High
Adhesions 2 28.04 Quite Low
Increased Venous Pressure Under Development 4 24.84 Low Low
Apoptosis 6 12.48 Low Low
Endotoxemia 2 10.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAF caused a translocation of STAT3 from the cytosol to the nuclei of enterocytes and the PAF-induced induction of TLR4 expression was inhibited by pharmacological inhibition of the STAT3 and NFkB signaling pathways.


PAF Positive_regulation (caused) of Localization (translocation) of STAT3 in enterocytes
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.78 Pain Relevance 0.15
Platelet-activating factor induces STAT3 phosphorylation and nuclear translocation in intestinal epithelial cells
Platelet-activating factor Positive_regulation (induces) of Localization (translocation) of STAT3 in epithelial cells
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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