INT337304

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.99
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTAFR, TLR4) signal transduction (TLR4) nucleolus (PTAFR)
intracellular (TLR4) nucleus (PTAFR) cytoplasm (TLR4)
Anatomy Link Frequency
epithelial cells 4
enterocytes 2
intestinal epithelium 2
Platelet 2
PTAFR (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 84 89.04 High High
cytokine 18 88.00 High High
Inflammatory response 12 74.44 Quite High
Inflammatory mediators 6 64.60 Quite High
anesthesia 6 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neonatal Necrotizing Enterocolitis 204 99.36 Very High Very High Very High
INFLAMMATION 84 89.04 High High
Apoptosis 18 88.48 High High
Injury 60 77.44 Quite High
Necrosis 6 75.72 Quite High
Colitis 6 72.00 Quite High
Infection 6 67.64 Quite High
Hypoxia 12 67.20 Quite High
Colon Cancer 6 64.16 Quite High
Inflammatory Bowel Disease 12 53.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet-activating factor increases TLR4 protein expression in intestinal epithelial cells
Platelet-activating factor Positive_regulation (increases) of Gene_expression (expression) of TLR4 protein in epithelial cells
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.09 Pain Relevance 0
We found that PAF is able to upregulate the normally low TLR4 expression in rat intestinal epithelium in vivo and in both human and rat IEC in tissue culture.
PAF Positive_regulation (upregulate) of Gene_expression (expression) of TLR4 in intestinal epithelium
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.61 Pain Relevance 0.06
These results indicate that LPS could stimulate IEC secretion of IL-8, but only if TLR4 expression was first induced by treating the cells with PAF and later stimulated with TLR4 ligand.
PAF Positive_regulation (induced) of Gene_expression (expression) of TLR4
3) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.15 Pain Relevance 0
Platelet-activating factor induces TLR4 mRNA expression and promotes IL-8 secretion in intestinal epithelial cells
Platelet-activating factor Positive_regulation (induces) of Gene_expression (expression) of TLR4 mRNA in epithelial cells
4) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.28 Pain Relevance 0.07
Platelet-activating factor induces TLR4 expression in the rat intestinal mucosa
Platelet-activating factor Positive_regulation (induces) of Gene_expression (expression) of TLR4 in Platelet
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.17 Pain Relevance 0.09
PAF caused a translocation of STAT3 from the cytosol to the nuclei of enterocytes and the PAF-induced induction of TLR4 expression was inhibited by pharmacological inhibition of the STAT3 and NFkB signaling pathways.


PAF-induced Positive_regulation (induction) of Gene_expression (expression) of TLR4 in enterocytes
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.69 Pain Relevance 0.14

General Comments

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