INT337310

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTAFR, TLR4) signal transduction (TLR4) nucleolus (PTAFR)
intracellular (TLR4) nucleus (PTAFR) cytoplasm (TLR4)
Anatomy Link Frequency
enterocytes 2
intestinal epithelium 2
PTAFR (Homo sapiens)
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 92.00 High High
Inflammation 42 91.60 High High
Inflammatory response 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neonatal Necrotizing Enterocolitis 102 99.64 Very High Very High Very High
INFLAMMATION 42 91.60 High High
Colon Cancer 3 10.64 Low Low
Injury 30 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Hypoxia 6 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 6 5.00 Very Low Very Low Very Low
Mucositis 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that Toll-like receptors (TLRs) are expressed at low levels in enterocytes of the mature gastrointestinal tract, but were shown to be aberrantly over-expressed in enterocytes in experimental NEC, we examined the regulation of TLR4 expression and signaling by PAF in intestinal epithelial cells using human and mouse in vitro cell lines, and the ex vivo rat intestinal loop model.
PAF Spec (examined) Regulation (regulation) of Spec (examined) Gene_expression (expression) of TLR4 in enterocytes associated with neonatal necrotizing enterocolitis
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955554 Disease Relevance 0.43 Pain Relevance 0
Our earlier studies have shown that in rodent models of necrotizing enterocolitis where PAF plays an important role, TLR4 expression is aberrantly elevated in the intestinal epithelium, implicating PAF in the regulation of TLR4 expression.
PAF Regulation (regulation) of Gene_expression (expression) of TLR4 in intestinal epithelium associated with neonatal necrotizing enterocolitis
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.19 Pain Relevance 0.09
In order to test whether PAF can regulate TLR4 expression, we developed a perfused ileal loop model, where the effect of intraluminal perfusion of PAF on gene expression can be directly evaluated.
PAF Regulation (regulate) of Gene_expression (expression) of TLR4
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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