INT337317

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Context Info
Confidence 0.51
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.88
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 4
epithelial cells 2
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 135 99.80 Very High Very High Very High
calcitonin gene related peptide 80 99.62 Very High Very High Very High
antagonist 90 99.22 Very High Very High Very High
chemokine 45 99.20 Very High Very High Very High
Inflammation 199 98.98 Very High Very High Very High
Inflammatory mediators 71 95.20 Very High Very High Very High
addiction 1 90.80 High High
cytokine 48 89.92 High High
qutenza 30 89.76 High High
agonist 10 75.40 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 5 99.52 Very High Very High Very High
Esophageal Disease 110 99.08 Very High Very High Very High
INFLAMMATION 254 98.98 Very High Very High Very High
Injury 35 97.00 Very High Very High Very High
Acid Reflux 15 88.88 High High
Celiac Disease 5 80.88 Quite High
Gastroesophageal Reflux Disease 60 69.04 Quite High
Death 5 59.28 Quite High
Neonatal Necrotizing Enterocolitis 34 57.36 Quite High
Hyperplasia 5 53.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, in an animal model of acute esophagitis, Paterson et al13 showed that acid perfusion caused release of platelet activating factor (PAF) from esophageal mucosa into the lumen and induced significant epithelial injury, prevented by a PAF-antagonist.
Positive_regulation (caused) of Localization (release) of PAF in platelet associated with esophageal disease, antagonist and injury
1) Confidence 0.51 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.22 Pain Relevance 0.46
In light of PAF's ability to activate NF-?
Positive_regulation (activate) of Localization (ability) of PAF
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.32 Pain Relevance 0.12
In addition, in an animal model of acute esophagitis, Paterson et al13 showed that acid perfusion caused release of platelet activating factor (PAF) from esophageal mucosa into the lumen and induced significant epithelial injury, prevented by a PAF-antagonist.
Positive_regulation (caused) of Localization (release) of platelet activating factor in platelet associated with esophageal disease, antagonist and injury
3) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.22 Pain Relevance 0.46
In contrast, a selective IL-8 antibody, a PAF receptor antagonist, and an neurokinin-1 receptor antagonist (ie, SP antagonist) significantly reduced PBL migration, supporting a role of IL-8, PAF and SP as relevant chemokines.
Positive_regulation (supporting) of Localization (role) of PAF associated with chemokine, antagonist and substance p
4) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.38 Pain Relevance 0.61
This indicates the existence of a self-perpetuating cycle of inflammation and motility abnormalities that is started by HCl-induced PAF release from the esophageal mucosa.
Positive_regulation (induced) of Localization (release) of PAF associated with inflammation and congenital anomalies
5) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.48 Pain Relevance 0.20
We conclude that HCl-induced activation of TRPV1 receptors in esophageal epithelial cells results in neurally mediated release of SP and CGRP, and non-neurally mediated release of PAF from the epithelium (Fig. 9).

7.

Positive_regulation (mediated) of Localization (release) of PAF in epithelial cells associated with calcitonin gene related peptide and substance p
6) Confidence 0.34 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.27 Pain Relevance 0.65

General Comments

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