INT337324

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PIK3CD, ITPR3) nucleoplasm (ITPR3) cell differentiation (PIK3CD)
small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3) transmembrane transport (ITPR3)
PIK3CD (Homo sapiens)
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 66 92.28 High High
agonist 10 74.80 Quite High
Kinase C 13 70.56 Quite High
antagonist 3 25.16 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 13 50.00 Quite Low
Anaplastic Astrocytoma 4 11.32 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Nociception 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PI3K has been found to mediate phosphorylation and translocation of phospholipase C-gamma and resultant IP3 production in response to activation of P2Y purinergic receptors - this could be one mechanism by which PI3 kinase inhibitors inhibit both the initial response to ATP and the resensitization of P2Y purinergic receptors [38].
PI3K Positive_regulation (mediate) of Gene_expression (production) of IP3
1) Confidence 0.02 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.43

General Comments

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