INT337348

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
spinal cord 2
HGF 2
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 30 97.32 Very High Very High Very High
Spinal cord 98 96.48 Very High Very High Very High
cytokine 4 85.56 High High
Peripheral nervous system 4 76.64 Quite High
Central nervous system 22 75.72 Quite High
ischemia 14 20.20 Low Low
Spinal nerve ligature 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 17 95.76 Very High Very High Very High
Amputation 6 89.20 High High
Nervous System Injury 4 75.76 Quite High
Spinal Cord Injury 24 70.84 Quite High
Hypertrophy 4 67.60 Quite High
Increased Venous Pressure Under Development 1 58.60 Quite High
Cardiovascular Disease 1 37.68 Quite Low
Disease 1 32.68 Quite Low
Cancer 4 21.44 Low Low
Cv Unclassified Under Development 14 20.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This could be due to the amount of GFAP the cell produces and is regulated by FGF-2 presence, which refers to astrocytic activation (Reeves et al., 1989).
Regulation (regulated) of Gene_expression (presence) of FGF-2
1) Confidence 0.45 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.07 Pain Relevance 0.07
We demonstrated a long-lasting up-regulation of FGF-2 mRNA expression in response to spinal transection at the mid trunk level, both in brainstem and in the spinal cord below injury.
Regulation (regulation) of Gene_expression (expression) of FGF-2 mRNA in spinal cord associated with medulla, injury and spinal cord
2) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.41 Pain Relevance 0.33
On the other hand, the expression of bFGF, HGF or IGF was not affected in this study.
Neg (not) Regulation (affected) of Gene_expression (expression) of bFGF in HGF
3) Confidence 0.26 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2955572 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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