INT33735

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 39
Total Number 40
Disease Relevance 14.23
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANGPTL5) extracellular space (ANGPTL5) extracellular region (ANGPTL5)
Anatomy Link Frequency
platelet 22
plasma 1
blood 1
synovial fluids 1
red blood cell 1
ANGPTL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 190 99.08 Very High Very High Very High
Inflammatory response 73 98.56 Very High Very High Very High
antagonist 31 98.32 Very High Very High Very High
Angina 31 97.40 Very High Very High Very High
aspirin 165 96.20 Very High Very High Very High
agonist 39 90.80 High High
opioid receptor 1 83.92 Quite High
local anesthetic 8 82.92 Quite High
Opioid 1 82.76 Quite High
Serotonin 14 81.76 Quite High
Disease Link Frequency Relevance Heat
Disease 121 100.00 Very High Very High Very High
Cardiovascular Disease 36 100.00 Very High Very High Very High
Acidosis 10 99.12 Very High Very High Very High
INFLAMMATION 308 99.08 Very High Very High Very High
Stroke 22 98.72 Very High Very High Very High
Myocardial Infarction 83 98.32 Very High Very High Very High
Thrombosis 100 98.28 Very High Very High Very High
Injury 73 98.28 Very High Very High Very High
Cv General 3 Under Development 31 97.40 Very High Very High Very High
Increased Venous Pressure Under Development 34 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, inhibitors of fibrinogen binding to the receptor may constitute an efficient way of preventing thrombus formation.
fibrinogen Binding (binding) of associated with thrombosis
1) Confidence 0.32 Published 1994 Journal Ups. J. Med. Sci. Section Abstract Doc Link 7716823 Disease Relevance 0.56 Pain Relevance 0.20
MK-852 is a newly developed low molecular weight inhibitor of fibrinogen binding to platelets.
fibrinogen Binding (binding) of in platelets
2) Confidence 0.32 Published 1994 Journal Ups. J. Med. Sci. Section Abstract Doc Link 7716823 Disease Relevance 0.48 Pain Relevance 0.12
In contrast, chymotrypsin-treated platelets sustained 50% inhibition of fibrinogen binding when incubated with 0.4 to 0.5 mmol/L DB, and kinetic analysis showed that the high-affinity platelet-fibrinogen interactions were reduced but not absent.
fibrinogen Binding (binding) of in platelets
3) Confidence 0.30 Published 1986 Journal Blood Section Abstract Doc Link 3015284 Disease Relevance 0 Pain Relevance 0.15
At higher concentrations of DB (approximately 1 mmol/L), ADP-induced fibrinogen binding was completely blocked.
fibrinogen Binding (binding) of
4) Confidence 0.30 Published 1986 Journal Blood Section Abstract Doc Link 3015284 Disease Relevance 0 Pain Relevance 0.15
Complete inhibition of ADP-induced aggregation was achieved five minutes after platelet exposure to 0.10 to 0.25 mmol/L of DB when fibrinogen binding was reduced by 50%.
fibrinogen Binding (binding) of in platelet
5) Confidence 0.30 Published 1986 Journal Blood Section Abstract Doc Link 3015284 Disease Relevance 0 Pain Relevance 0.16
On the other hand, studies of polymorphisms associated with fibrinogen levels [7,8] have been equivocal regarding the relationship of the former with clinical events of CHD.
fibrinogen Binding (associated) of associated with coronary artery disease
6) Confidence 0.29 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.58 Pain Relevance 0.06
Platelet aggregation requires binding of fibrinogen to the GPIIb/IIIa receptor on the platelet surface.
fibrinogen Binding (binding) of in platelet
7) Confidence 0.24 Published 1994 Journal Ups. J. Med. Sci. Section Abstract Doc Link 7716823 Disease Relevance 0.56 Pain Relevance 0.20
Inhibition of fibrinogen binding to platelets by MK-852, a new GPIIb/IIIa antagonist.
fibrinogen Binding (binding) of in platelets associated with antagonist
8) Confidence 0.24 Published 1994 Journal Ups. J. Med. Sci. Section Title Doc Link 7716823 Disease Relevance 0.51 Pain Relevance 0.19
We have used flow cytometry and FITC-labelled chicken anti-human fibrinogen antibodies to study the in vitro inhibitory effects of MK-852 on fibrinogen binding to platelets.
fibrinogen Binding (binding) of in platelets
9) Confidence 0.24 Published 1994 Journal Ups. J. Med. Sci. Section Abstract Doc Link 7716823 Disease Relevance 0.50 Pain Relevance 0.21
Fibrinogen binding to chymotrypsin-treated platelets could not be completely inhibited even at high DB concentrations (1 mmol/L).
Fibrinogen Binding (binding) of in platelets
10) Confidence 0.23 Published 1986 Journal Blood Section Abstract Doc Link 3015284 Disease Relevance 0 Pain Relevance 0.14
Since complexes of fibronectin--fibrin--fibrinogen are known to be cold-insoluble, such interactions could occur in synovial fluids and contribute to the formation of cryoprecipitates.
fibrinogen Binding (interactions) of in synovial fluids
11) Confidence 0.18 Published 1981 Journal Arthritis Rheum. Section Abstract Doc Link 7317115 Disease Relevance 0.47 Pain Relevance 0.16
Flow cytometry was performed for measurement of fibrinogen binding, platelet surface expression of P-selectin, and microparticles.
fibrinogen Binding (binding) of in platelet
12) Confidence 0.16 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
FK633 inhibited platelet aggregation and fibrinogen binding to platelets throughout recirculation.
fibrinogen Binding (binding) of in platelets
13) Confidence 0.16 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
This hypothesis is supported by the literature, which has reported no significant association between ambient pollution and fibrinogen at low levels of exposure (Pope et al. 2004; Rückerl et al. 2006) but significant associations with high exposures such as during high air pollution episodes or controlled human exposure studies (Ghio et al. 2000).
fibrinogen Neg (no) Binding (association) of
14) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.59 Pain Relevance 0.19
Fibrinogen was not significantly associated with any of the pollutants considered in this investigation.
Fibrinogen Binding (associated) of
15) Confidence 0.12 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.46 Pain Relevance 0.18
These results suggest that FK633 inhibits the amplification loop by reducing the binding of fibrinogen to glycoprotein IIb/IIIa and platelet aggregation.


fibrinogen Binding (binding) of in platelet
16) Confidence 0.12 Published 2004 Journal Thromb. Res. Section Body Doc Link 15183042 Disease Relevance 0 Pain Relevance 0
To determine the importance of implant-bound fibrinogen in triggering biomaterial-mediated inflammatory responses in humans, PET disks precoated with the plasma or serum of each volunteer were implanted subcutaneously and then retrieved 24 hours later.
fibrinogen Binding (bound) of in plasma associated with inflammatory response
17) Confidence 0.10 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.39 Pain Relevance 0.10
Antithrombotic peptides inhibit the fibrinogen binding to a specific receptor region on the platelet surface and also inhibit aggregation of platelets.
fibrinogen Binding (binding) of in platelet
18) Confidence 0.10 Published 1997 Journal Biopolymers Section Abstract Doc Link 9216247 Disease Relevance 0 Pain Relevance 0.12
Many activation-dependent platelet surface receptor changes are species specific; however, fibrinogen appears to be conserved across species.
fibrinogen Binding (appears) of in platelet
19) Confidence 0.10 Published 1994 Journal Vet. Pathol. Section Abstract Doc Link 7801433 Disease Relevance 0.05 Pain Relevance 0.13
This hypothesis is supported by literature considering air pollution and disturbances in hemostasis in general (Baccarelli et al. 2007, 2008; Nemmar et al. 2006), although studies considering the specific association between air pollutants and fibrinogen report conflicting results (Chuang et al. 2007; Pekkanen et al. 2000; Rückerl et al. 2007; Seaton et al. 1999; Steinvil et al. 2008).
fibrinogen Binding (association) of
20) Confidence 0.09 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2831955 Disease Relevance 0.21 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox