INT33739

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 8.19
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA2B) plasma membrane (ITGA2B)
Anatomy Link Frequency
platelet 15
plasma 2
monocytes 1
cartilage 1
ITGA2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 9 99.00 Very High Very High Very High
aspirin 41 98.32 Very High Very High Very High
diclofenac 6 98.26 Very High Very High Very High
Angina 16 98.04 Very High Very High Very High
anesthesia 7 97.88 Very High Very High Very High
Osteoarthritis 84 97.26 Very High Very High Very High
Cannabinoid receptor 4 95.32 Very High Very High Very High
ischemia 6 94.24 High High
antagonist 26 93.76 High High
Pain 29 92.20 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 16 98.04 Very High Very High Very High
Frailty 85 97.26 Very High Very High Very High
Coronary Artery Disease 28 97.12 Very High Very High Very High
Adhesions 12 96.72 Very High Very High Very High
Injury 10 95.28 Very High Very High Very High
Rupture 1 94.72 High High
Peripheral Arterial Disease 7 94.32 High High
Cv Unclassified Under Development 6 94.24 High High
Atherosclerosis 4 93.60 High High
Pain 26 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We evaluated the influence of the duration of cold preservation time on the expression of platelet GPIIb/IIIa and P-selectin and on the formation of leukocyte-platelet complexes after kidney transplantation.
Gene_expression (expression) of GPIIb in platelet
1) Confidence 0.75 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.63 Pain Relevance 0.21
However, there was a highly significant increase of platelet activity as assessed by conventional aggregometry (P=.0003), Ultegra analyzer readings (P=.03), and expression of GPIIb/IIIa (P=.02), P-selectin (P=.03), and platelet endothelial cell adhesion molecule-1 (P=.001) after withdrawal from NSAIDs and COX-2 inhibitors.
Spec (analyzer) Gene_expression (expression) of GPIIb in platelet
2) Confidence 0.75 Published 2006 Journal Am. J. Med. Section Body Doc Link 16887419 Disease Relevance 0 Pain Relevance 0
METHODS: We studied changes in adhesion molecule expression of platelets (GPIIb/IIIa), neutrophils--CD18, CD11b and L-selectin--and monocytes (CD14) after interaction with active lesions of patients with stable angina subjected to PTCA and patients with unstable angina (UA).
Gene_expression (expression) of GPIIb in monocytes
3) Confidence 0.75 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771923 Disease Relevance 0.19 Pain Relevance 0
GPIIb/IIIa and P-selectin expression on circulating platelets were significantly decreased in the long and the short-term graft preservation group compared with healthy volunteers.
Gene_expression (expression) of GPIIb in platelets
4) Confidence 0.75 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.45 Pain Relevance 0.19
Surface expression of the GPIIb/IIIa, P-selectin and the percentage of platelet-granulocyte complexes were quantified by flow cytometry.
Gene_expression (expression) of GPIIb in platelet
5) Confidence 0.75 Published 2003 Journal Clin Transplant Section Abstract Doc Link 14703928 Disease Relevance 0.50 Pain Relevance 0.21
METHODS: By flow cytometry and special labelled antibodys to detect the whole blood platelet membranous glycoprotein CD62P and CD41/45 expressions in UA patients before and after XCP treatment, as well as those in peripheral blood of AMI rats before and after co-cultured with XCP containing serum from patients at 37 degrees C for 30 min.
Gene_expression (expressions) of CD41 in blood platelet
6) Confidence 0.75 Published 2002 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12584788 Disease Relevance 0 Pain Relevance 0
RESULTS: CD62P and CD41/45 expressions increased significantly in UA patients to 24.36 +/- 7.91% and 29.51 +/- 12.21% respectively.
Gene_expression (expressions) of CD41
7) Confidence 0.75 Published 2002 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 12584788 Disease Relevance 0 Pain Relevance 0
Moreover, immunocytofluorimetry demonstrated that diclofenac dose-dependently (100-500 microM) induced the expression of GMP-140 and increased the expression of GPIIb/IIIa on the membrane of unstimulated platelets.
Gene_expression (expression) of GPIIb in platelets associated with diclofenac
8) Confidence 0.75 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735806 Disease Relevance 0.47 Pain Relevance 0.24
High doses ( > 500 microM) of this drug inhibited thrombin-stimulated expression of GPIIb/IIIa and GMP-140.
Gene_expression (expression) of GPIIb
9) Confidence 0.75 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735806 Disease Relevance 0.44 Pain Relevance 0.23
We demonstrated significantly increased expression of GP53 and activated GPIIb/IIIa on the platelet surface using a sensitive flow cytometric method of detection.
Gene_expression (expression) of GPIIb in platelet
10) Confidence 0.75 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8735809 Disease Relevance 0.45 Pain Relevance 0.15
Measurements were performed for (1) platelet surface activation, assessing flow cytometric expression of activated integrin alpha(IIb)beta(3) receptor (GPIIb/IIIa, CD41a) and P-selectin (CD62p); (2) platelet and erythrocyte surface procoagulant activities, measuring flow cytometric binding of activated factor (FVa) and annexin V; (3) plasma levels of platelet-specific secreted proteins platelet factor 4 (PF4) and beta-thromboglobulin (betaTG); (4) plasma markers of thrombin generation, prothrombin activation fragment (F(1.2)), and thrombin: antithrombin complex (TAT); and (5) plasma markers of fibrinolysis, D -dimer, and plasmin:antiplasmin complex (PAP).
Gene_expression (expression) of GPIIb in plasma
11) Confidence 0.65 Published 2001 Journal J. Lab. Clin. Med. Section Abstract Doc Link 11385360 Disease Relevance 0.49 Pain Relevance 0.18
The concentration of platelets GPII b/IIIa and GP Ib/IX was estimated by ELISA method using monoclonal antibody against GPII b/IIIa (CD41a) and GPI b/IX (CD42a Immunotech).
Gene_expression (concentration) of GPII b in platelets
12) Confidence 0.65 Published 2003 Journal Int Angiol Section Body Doc Link 12865882 Disease Relevance 0.28 Pain Relevance 0
Figure 1Graph showing the increased inhibition of residual ADP-induced P-selectin positive platelets (a) and expression of activated GPIIb/IIIa (b) after the further blocking of the P2Y12 receptor with AR-C 69931 (10 ?
Gene_expression (expression) of GPIIb in platelets
13) Confidence 0.65 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0.19
Thrombin-induced platelet-fibrin clot strength (MA), time to initial platelet-fibrin clot formation (R), C-reactive protein (CRP), prothrombotic factors, activated GPIIb/IIIa receptor expression and other biomarkers were studied in patients with asymptomatic stable CAD (AS), in patients undergoing PCI for stable (SA) and unstable angina (UA).
Gene_expression (expression) of GPIIb in platelet associated with angina and coronary artery disease
14) Confidence 0.58 Published 2010 Journal Platelets Section Abstract Doc Link 20377327 Disease Relevance 1.29 Pain Relevance 0.39
However, CD42b, CD41/61 and CD62p expression returned to the pre-operative level in group V.
Gene_expression (expression) of CD41
15) Confidence 0.58 Published 2006 Journal Acta Anaesthesiol Scand Section Body Doc Link 16987338 Disease Relevance 0 Pain Relevance 0
The expression of CD42b, CD41/61 and CD62p in vivo was assessed on non-stimulated platelets and adenosine diphosphate (ADP) agonist-activated platelets using flow cytometry.
Gene_expression (expression) of CD41 in platelets
16) Confidence 0.58 Published 2006 Journal Acta Anaesthesiol Scand Section Body Doc Link 16987338 Disease Relevance 0 Pain Relevance 0
=19) and the expression of activated GPIIb/IIIa by 43.5±3.4%.
Gene_expression (expression) of GPIIb
17) Confidence 0.58 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0.24
MA and R were measured by thrombelastography, GPIIb/IIIa expression by flow cytometry and all other markers by fluorokine multianalyte profiling assays.
Gene_expression (expression) of GPIIb
18) Confidence 0.58 Published 2010 Journal Platelets Section Abstract Doc Link 20377327 Disease Relevance 1.57 Pain Relevance 0.46
HES200/0.5 and HES130/0.4 reduced the CD42b, CD41/61 and CD62p expression of ADP-agonist-activated platelets at 15 min after intravenous infusion.
Gene_expression (expression) of CD41 in platelets
19) Confidence 0.58 Published 2006 Journal Acta Anaesthesiol Scand Section Body Doc Link 16987338 Disease Relevance 0 Pain Relevance 0
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and radioelectroimmunoassay of DB-treated platelets, however, showed no evidence of a reduction or degradation of GP IIb or IIIa.
Gene_expression (reduction) of GP IIb in platelets
20) Confidence 0.53 Published 1986 Journal Blood Section Abstract Doc Link 3015284 Disease Relevance 0 Pain Relevance 0.07

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