INT337417

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

histone binding (LEF1) cell adhesion (LEF1) nucleus (LEF1)
DNA binding (LEF1) transcription factor binding (LEF1) cytoplasm (LEF1)
Anatomy Link Frequency
fin 1
MIR203 (Homo sapiens)
LEF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 14 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Cancer 26 84.76 Quite High
Meningioma 4 52.04 Quite High
Adhesions 8 30.52 Quite Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Gastrointestinal Neoplasms 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, repression of Lef1 by miR-203 blocks fin regeneration, whereas loss of miR-203 results in excess Lef1 levels and fin overgrowth.


miR-203 Negative_regulation (repression) of Lef1 in fin associated with repression
1) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.26 Pain Relevance 0
Expression of Lef1 from mRNAs lacking 3'UTR recognition elements can rescue the effects of excess miR-203, demonstrating that these effects are due to specific regulation of Lef1 by miR-203.
miR-203 Negative_regulation (regulation) of Lef1
2) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.31 Pain Relevance 0

General Comments

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