INT3375

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Context Info
Confidence 0.77
First Reported 1976
Last Reported 2010
Negated 27
Speculated 2
Reported most in Body
Documents 535
Total Number 538
Disease Relevance 387.47
Pain Relevance 65.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eosinophils 28
skin 23
mast cells 23
blood 13
B cells 13
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5540 100.00 Very High Very High Very High
cytokine 4276 100.00 Very High Very High Very High
chemokine 708 100.00 Very High Very High Very High
anesthesia 78 100.00 Very High Very High Very High
Paracetamol 67 100.00 Very High Very High Very High
Morphine 32 100.00 Very High Very High Very High
cocaine 4 100.00 Very High Very High Very High
Pain 154 99.88 Very High Very High Very High
alcohol 96 99.84 Very High Very High Very High
Multiple sclerosis 23 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 11913 100.00 Very High Very High Very High
INFLAMMATION 5861 100.00 Very High Very High Very High
Rhinitis 3011 100.00 Very High Very High Very High
Chronic Sinusitis 1589 100.00 Very High Very High Very High
Syndrome 1387 100.00 Very High Very High Very High
Gastroenteritis 115 100.00 Very High Very High Very High
Repression 12 100.00 Very High Very High Very High
Multiple Myeloma 196 99.96 Very High Very High Very High
Staphylococcus Infection 118 99.96 Very High Very High Very High
Spondylarthropathies 1 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These are the underlying mechanisms in intolerance of analgesics, and contrast media as well as anaphylactoid reactions after infusion of plasma substituents, first exact data on the determination of the high production of IgE, the specific sensitization, and the special manifestation by genetic factors.
Gene_expression (production) of IgE in plasma associated with analgesic
1) Confidence 0.77 Published 1986 Journal Z Gesamte Inn Med Section Abstract Doc Link 3491471 Disease Relevance 0.30 Pain Relevance 0.10
The immunologic basis of asthma is widely accepted for allergic asthma, and the synthesis of IgE is dependent on cytokines.
Gene_expression (synthesis) of IgE associated with asthma and cytokine
2) Confidence 0.77 Published 1997 Journal Curr Opin Pulm Med Section Abstract Doc Link 9139771 Disease Relevance 0.96 Pain Relevance 0.21
However, in both cases no specific IgE could be detected.
Gene_expression (detected) of IgE
3) Confidence 0.77 Published 1996 Journal J. Allergy Clin. Immunol. Section Body Doc Link 8655888 Disease Relevance 0 Pain Relevance 0
An important aspect of our case was the unreliability of quantitative IgE levels in the assessment of disease response, due to the prozone effect.
Gene_expression (levels) of IgE associated with disease
4) Confidence 0.77 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2944146 Disease Relevance 1.62 Pain Relevance 0
IgE production is not impaired by the pathologic process in MM patients.
Gene_expression (production) of IgE associated with multiple myeloma
5) Confidence 0.76 Published 2004 Journal Rinsho Ketsueki Section Abstract Doc Link 15199753 Disease Relevance 0.69 Pain Relevance 0.17
IL-4 is the main cytokine responsible for IgE production, inducing antibody isotype switching from IgG and IgM to IgE [10].
Gene_expression (production) of IgE associated with cytokine
6) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.52 Pain Relevance 0.11
High levels of circulating IL-4 have also been associated with a greater parasite antigen-specific production of IgE in individuals less susceptible to malaria [13].
Gene_expression (production) of IgE associated with malaria
7) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.77 Pain Relevance 0.09
Also, no significant correlation was found between both IgE and TNF levels in the CM group.
Gene_expression (levels) of IgE associated with cerebral malaria
8) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.84 Pain Relevance 0.04
This increase in IgE production between 0 and six years of age may also reflect an increase in the capacity of the immune system to respond to parasite infections [7,27].
Gene_expression (production) of IgE in immune system associated with infection
9) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.82 Pain Relevance 0.04
Therefore, the normal value (N) was defined by the median IgE levels in the endemic controls of each study population.
Gene_expression (levels) of IgE
10) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.83 Pain Relevance 0
However, the level of IgE production was correlated to IL-10 levels in UM and AI patients (Figure 4).
Gene_expression (production) of IgE associated with malaria
11) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.83 Pain Relevance 0.12
It has been shown experimentally that there are conditions under which alternative mechanisms may induce IgE production independent of IL-4 [44].
Gene_expression (production) of IgE
12) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.31 Pain Relevance 0.08
Although the median total IgE levels in the Indian NEC groups was higher than that of the Gabonese EC group, suggesting that age could be an important factor in IgE production, the higher IgE levels in the Indian population may also be interpreted as the result of either environmental factors, such as predominance of food allergies, of the genetic background, which may predispose to developing IgE responses [13,27,29-32] or of a co-infection with other parasites, such as helminths affecting the IgE responses in these patients [33,34].
Gene_expression (production) of IgE associated with food hypersensitivity and infection
13) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.44 Pain Relevance 0
Previous studies have used ELISA to quantify specific IgE present in the serum [7,8,10,11].
Gene_expression (present) of IgE
14) Confidence 0.76 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.52 Pain Relevance 0
Most zoonotic helminthes induced immune response (Nutman, 2001) characterized by producing of type 2 cytokines, Ig G1, IgG2, IgE antibodies and eosinophil and mast cell activation (Hoffman et al., 2002).
Gene_expression (producing) of IgE in mast cell associated with cytokine
15) Confidence 0.75 Published 2008 Journal J Egypt Soc Parasitol Section Abstract Doc Link 19209761 Disease Relevance 0.69 Pain Relevance 0.05
An in vivo AHR accompanied by increased IgE production and pulmonary eosinophilia has been demonstrated in the actively sensitized and repeatedly OA-challenged BALB/c strain of mice [20].
Gene_expression (production) of IgE associated with sprains and strains and pulmonary eosinophilia
16) Confidence 0.75 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.20 Pain Relevance 0
Most patients with proven or suspected enteric infection with the common hookworm of dogs, Ancylostoma caninum, produce immunoglobulin G (IgG) and IgE antibodies to an immunodominant excretory/secretory antigen (Ac68) of the parasite.
Gene_expression (produce) of IgE in excretory associated with ancylostoma infection, hookworm infection and infection
17) Confidence 0.75 Published 1996 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 8686791 Disease Relevance 0.50 Pain Relevance 0
Levels of IgE in the serum of patients with coronary arterial disease.
Gene_expression (Levels) of IgE associated with disease
18) Confidence 0.75 Published 1991 Journal Int. J. Cardiol. Section Title Doc Link 1869329 Disease Relevance 0.99 Pain Relevance 0.35
However, its effect on IgE synthesis is unknown.
Gene_expression (synthesis) of IgE
19) Confidence 0.73 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Abstract Doc Link 15478383 Disease Relevance 0 Pain Relevance 0
Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis.
Gene_expression (synthesis) of IgE in nasal associated with headache
20) Confidence 0.73 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Title Doc Link 15478383 Disease Relevance 0 Pain Relevance 0.10

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