INT33759

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Context Info
Confidence 0.00
First Reported 1986
Last Reported 1986
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hmmr, Akr1d1) cytosol (Akr1d1) oxidoreductase activity (Akr1d1)
cytoskeleton organization (Hmmr) cell-cell signaling (Hmmr)
Hmmr (Rattus norvegicus)
Akr1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 6 100.00 Very High Very High Very High
opiate 10 99.90 Very High Very High Very High
Morphine 2 97.96 Very High Very High Very High
Dopamine 6 96.24 Very High Very High Very High
narcan 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D1 dopamine receptor-mediated activation of adenylate cyclase by SKF38393 was inhibited by morphine in an additive fashion, but the opiate had minimal effects on the net activation of adenylate cyclase by dopamine which activates both D1 and D2 receptors.
receptor-mediated Positive_regulation (activation) of D1 associated with dopamine, dopamine receptor, opiate and morphine
1) Confidence 0.00 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3015643 Disease Relevance 0 Pain Relevance 0.77
From these results it would appear that opiate and D1 dopamine receptor-mediated activation of adenylate cyclase summate, but that opiate and D2 dopamine receptors regulate a common pool of adenylate cyclase in striatal membranes.
receptor-mediated Positive_regulation (activation) of D1 associated with dopamine receptor and opiate
2) Confidence 0.00 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3015643 Disease Relevance 0 Pain Relevance 0.81

General Comments

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