INT337637

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SIRT1, TP53) nucleoplasm (SIRT1, TP53) mitochondrion (SIRT1, TP53)
enzyme binding (SIRT1, TP53) cytoplasm (SIRT1, TP53) nucleolus (SIRT1, TP53)
Anatomy Link Frequency
colon 1
SIRT1 (Homo sapiens)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 1 98.44 Very High Very High Very High
Colon Cancer 9 96.86 Very High Very High Very High
Cancer 50 95.48 Very High Very High Very High
Colorectal Cancer 95 77.12 Quite High
Familial Adenomatous Polyposis 9 76.04 Quite High
Microsatellite Instability 11 73.84 Quite High
Disease 10 58.00 Quite High
Adenoma 9 45.12 Quite Low
Carcinoma 1 44.08 Quite Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of miR-34a is tightly regulated by p53, and ectopic expression of miR-34a in colon cancer cells causes remarkable reduction of cell proliferation and induces senescence-like phenotypes. miR-34a also down-regulates silent information regulator 1 (SIRT1), which is a class III histone deacetlylase and known to be a negative regulator of p53 through the modulation of acetylation at K382 of p53, and participates in the positive feedback loop of the p53 tumor suppressor network.
SIRT1 Negative_regulation (regulator) of p53 in colon associated with aging, cancer and colon cancer
1) Confidence 0.23 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.49 Pain Relevance 0

General Comments

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