INT337667

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
colon 2
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 9 100.00 Very High Very High Very High
Colon Cancer 9 97.86 Very High Very High Very High
Colorectal Cancer 95 83.08 Quite High
Disease 10 82.44 Quite High
Cancer 50 77.44 Quite High
Aging 1 60.08 Quite High
Microsatellite Instability 11 19.44 Low Low
Adenoma 9 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 4 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of SND1 in colon cancer cells caused down-regulation of APC and activation of the Wnt signaling pathway as a consequence, without altering APC mRNA levels.
Neg (without) Regulation (altering) of Transcription (levels) of APC in colon associated with familial adenomatous polyposis and colon cancer
1) Confidence 0.23 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.00 Pain Relevance 0

General Comments

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