INT33768

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Context Info
Confidence 0.46
First Reported 1986
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 87
Total Number 91
Disease Relevance 54.66
Pain Relevance 33.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cysltr1) plasma membrane (Cysltr1) signal transducer activity (Cysltr1)
Anatomy Link Frequency
synapses 10
spike 4
cortex 2
sputum 2
dendrites 1
Cysltr1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 2871 100.00 Very High Very High Very High
long-term potentiation 1059 100.00 Very High Very High Very High
antagonist 208 100.00 Very High Very High Very High
addiction 110 100.00 Very High Very High Very High
noradrenaline 15 99.98 Very High Very High Very High
Hippocampus 296 99.84 Very High Very High Very High
Anterior cingulate cortex 160 99.68 Very High Very High Very High
nMDA receptor 552 99.64 Very High Very High Very High
Serotonin 24 99.48 Very High Very High Very High
Spinal cord 19 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 2871 100.00 Very High Very High Very High
Injury 88 99.88 Very High Very High Very High
Sepsis 6 99.88 Very High Very High Very High
Respiratory Disease 504 99.84 Very High Very High Very High
Asthma 289 99.84 Very High Very High Very High
Heart Rate Under Development 1 99.84 Very High Very High Very High
Targeted Disruption 1163 99.82 Very High Very High Very High
Brain Injury 23 99.76 Very High Very High Very High
Cerebral Hypoxia 2 99.66 Very High Very High Very High
Pulmonary Disease 77 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased CysLT biosynthetic response to indomethacin during I/R was attenuated by TMK688.
Positive_regulation (increased) of CysLT
1) Confidence 0.46 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20042530 Disease Relevance 0.13 Pain Relevance 0.16
There was a trend for increased CysLT levels in Group I at baseline (p = 0.08), but no difference in PGE2 concentrations.
Positive_regulation (increased) of CysLT
2) Confidence 0.37 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2426667 Disease Relevance 0 Pain Relevance 0.19
Increased levels of cysLT were detected in BALF from adult and weanling mice (p = 0.029, 0.009 respectively), peaking at 5 d post RSV inoculation (Figure 11).
Positive_regulation (levels) of cysLT associated with respiratory syncytial virus
3) Confidence 0.17 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.99 Pain Relevance 0.03
Increased levels of cysLT were detected in BALF from adult and weanling mice (p = 0.029, 0.009 respectively), peaking at 5 d post RSV inoculation (Figure 11).
Positive_regulation (Increased) of cysLT associated with respiratory syncytial virus
4) Confidence 0.17 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 1.00 Pain Relevance 0.03
Increased responsiveness to aerosolised MCh was matched by elevated levels of cysLT at 5 d and elevated VEGF and PGE2 at 7 d in BALF from both adult and weanling mice.
Positive_regulation (elevated) of cysLT
5) Confidence 0.14 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1325022 Disease Relevance 0.87 Pain Relevance 0.04
Under systemic application of the dopamine D2-like receptor antagonist sulpiride, LTD significantly increased to 64%, again for at least 1 h.
Positive_regulation (increased) of LTD associated with dopamine, depression and antagonist
6) Confidence 0.10 Published 2005 Journal Brain Res. Section Abstract Doc Link 15713281 Disease Relevance 1.19 Pain Relevance 0.92
In rat microglia, the brain immune cells involved in the response to cerebral hypoxia and trauma, the activation of P2Y1 and CysLT receptors mediate co-release of nucleotides and cysLTs [7], which might, in turn, contribute to neuroinflammation and neurodegeneration.
Positive_regulation (activation) of CysLT in immune cells associated with cerebral hypoxia and injury
7) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 1.32 Pain Relevance 0.24
In summary, our study reveals the new cysLT/uracil nucleotide receptor GPR17 as a “sensor” that is activated upon brain injury in several embryonically distinct cell types (neurons, microglia and adult neural precursor cells) that contribute to damage evolution and to the subsequent remodeling and repair.
Positive_regulation (activated) of cysLT in precursor cells associated with brain injury
8) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.43 Pain Relevance 0.20
In contrast, the induction of HFS-LTD is reduced in the SDH of GluR2 mutants.
Positive_regulation (induction) of HFS-LTD associated with depression
9) Confidence 0.07 Published 2008 Journal Pain Section Abstract Doc Link 17826911 Disease Relevance 0.32 Pain Relevance 0.67
We next addressed the key prediction of the model by testing whether the same PF input would lead to a shorter pause after induction of LTD.
Positive_regulation (induction) of LTD associated with depression
10) Confidence 0.06 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.31 Pain Relevance 0.15
Future in vivo studies, in which pauses are measured during a learning task such as visuovestibular training (see e.g., Schonewille et al. [2006]), will be needed to provide more direct evidence for the relevance of pauses in vivo and their shortening by LTD induction.


Positive_regulation (induction) of LTD associated with depression
11) Confidence 0.06 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.36 Pain Relevance 0.18
Next, we showed directly that LTD induction reduced postburst pause duration and that the first spike latency and the number of spikes in the burst are poorer candidates for pattern recognition compared to the pause.
Positive_regulation (induction) of LTD in spike associated with depression
12) Confidence 0.06 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.31 Pain Relevance 0.15
Learning of patterns was implemented as a reduction of the AMPA receptor conductances of activated PF synapses, as is the case after induction of LTD (see Experimental Procedures).
Positive_regulation (induction) of LTD in synapses associated with depression
13) Confidence 0.06 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.39 Pain Relevance 0.20
Thus, a Purkinje-cell-specific impairment of induction of LTD is associated with the expected altered simple-spike firing patterns at rest and is even more pronounced during natural sensory stimulation.


Positive_regulation (induction) of LTD in spike associated with depression
14) Confidence 0.06 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.35 Pain Relevance 0.17
The average pause duration decreased from 82 ± 22 ms to 43 ± 9 ms after LTD induction, corresponding to a 65% ± 14% reduction (n = 6; Figure 4C).
Positive_regulation (induction) of LTD associated with depression
15) Confidence 0.06 Published 2007 Journal Neuron Section Body Doc Link PMC1885969 Disease Relevance 0.44 Pain Relevance 0.22
2 (T site) impairs LTD induction at PF-PC synapses and caused CF territory expansion, but had little effect on PF-PC synapse formation and elimination of surplus CFs at proximal dendrites of PCs [21].
Positive_regulation (induction) of LTD in dendrites associated with depression
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.28 Pain Relevance 0.70
Thus, Delphilin mutant mice should be useful for this plasticity enhancement approach because Delphilin is selectively localized at PF-PC synapses and its ablation facilitates LTD induction with little effect on the maximal amplitude of LTD expression.
Positive_regulation (induction) of LTD in synapses associated with depression
17) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.34 Pain Relevance 0.33
Thus, our results suggest the critical and rate-limiting role of LTD induction at PF-PC synapses in the neural network for OKR gain-increase adaptation, a simple form of motor learning.
Positive_regulation (induction) of LTD in neural associated with depression
18) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.40 Pain Relevance 0.23
2, mGluR1, AMPA receptors and Ca2+ are key mediators of LTD induction [36], [37].
Positive_regulation (induction) of LTD associated with depression
19) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.85 Pain Relevance 0.48
The decreased dependence on the intracellular Ca2+ appears to be the main cause of the facilitation of LTD induction in the mutant mice.
Positive_regulation (induction) of LTD associated with addiction and depression
20) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.64 Pain Relevance 0.51

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