INT33777

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Context Info
Confidence 0.15
First Reported 1982
Last Reported 1997
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.17
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 3 96.36 Very High Very High Very High
dopamine receptor 1 93.04 High High
agonist 3 88.16 High High
Clonidine 2 77.24 Quite High
antagonist 3 55.24 Quite High
Dopamine 1 53.60 Quite High
Potency 2 52.20 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 58.96 Quite High
Syndrome 1 58.00 Quite High
Muscle Hypertonia 1 51.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirdly, an addition of a methylenedioxy radical to the phenyl ring increased the affinity of the compounds to presynaptic alpha 2-receptor.
Positive_regulation (increased) of alpha 2 Binding (affinity) of
1) Confidence 0.15 Published 1986 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3016232 Disease Relevance 0 Pain Relevance 0.15
It is concluded that the efficacy which has been reported for the SKF-7265 induced reversal of reserpine rigidity and its potential value as an antispasticity agent may be attributed to its relatively high affinity for alpha-2 adrenergic receptors.
Spec (may) Positive_regulation (attributed) of alpha-2 Binding (affinity) of
2) Confidence 0.08 Published 1982 Journal Acta Neurol. Scand. Section Abstract Doc Link 6291304 Disease Relevance 0.17 Pain Relevance 0.24
Pentobarbital induced a desensibilization for alpha 2-receptors (8.3 +/- 0.5 vs 16.0 +/- 1.4 mmol/l Na+) and a sensibilization for alpha 3-receptors (14.4 +/- 0.8 vs 10 +/- 1.3 mmol/l Na+).
Positive_regulation (induced) of alpha 2 Binding (desensibilization) of
3) Confidence 0.08 Published 1997 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 9029486 Disease Relevance 0 Pain Relevance 0.12

General Comments

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