INT337805

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.89
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dgkb) kinase activity (Dgkb) cytoplasm (Dgkb)
Anatomy Link Frequency
cortex 1
Dgkb (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 20 99.00 Very High Very High Very High
member 8 4 98.12 Very High Very High Very High
Dopamine 4 75.80 Quite High
Eae 88 69.44 Quite High
cerebral cortex 8 65.04 Quite High
Hippocampus 12 62.56 Quite High
antidepressant 8 58.20 Quite High
depression 12 49.04 Quite Low
alcohol 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 336 99.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 40 89.96 High High
Manic Depressive Disorder 60 89.40 High High
Cognitive Disorder 12 85.80 High High
Schizophrenia 12 76.68 Quite High
Depression 20 49.04 Quite Low
Anxiety Disorder 64 43.04 Quite Low
Neurodegenerative Disease 4 15.12 Low Low
Mental Disorders 12 12.72 Low Low
Sprains And Strains 4 10.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of DGK to catalyze the phosphorylation of DG into PA is an intrinsic component of the phosphatidylinositol cycle.
Phosphorylation (phosphorylation) of DGK
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.16 Pain Relevance 0.14
On the other hand, the level of tau hyperphosphorylation in DGK?
Phosphorylation (hyperphosphorylation) of DGK
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.84 Pain Relevance 0.03
and tau hyperphosphorylation (using the AT8 antibody) in the cortex of WT and DGK?
Phosphorylation (cortex) of DGK in cortex
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0.89 Pain Relevance 0.04
Subsequently, DG is phosphorylated by diacylglycerol kinase (DGK) to produce phosphatidic acid (PA), an important lipid second messenger which regulates several key enzymes, including the target of rapamycin, atypical PKC and phosphatidylinositol-4-phosphate 5-kinase (PI4P5-kinase) [1], [2], [3], [4].
Phosphorylation (phosphorylated) of DGK associated with kinase c
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 0 Pain Relevance 0.30

General Comments

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