INT33781

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Context Info
Confidence 0.44
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.76
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pebp1) mitochondrion (Pebp1) extracellular space (Pebp1)
aging (Pebp1) Golgi apparatus (Pebp1) response to stress (Pebp1)
Anatomy Link Frequency
blood 1
ileum 1
brain 1
hippocampus 1
Pebp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 43 100.00 Very High Very High Very High
Hippocampus 10 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
MU agonist 2 100.00 Very High Very High Very High
diclofenac 4 99.80 Very High Very High Very High
Opioid 5 99.76 Very High Very High Very High
fortral 14 98.48 Very High Very High Very High
antinociception 4 97.76 Very High Very High Very High
Endogenous opioid 2 92.24 High High
Disease Link Frequency Relevance Heat
Learning Disorders 2 99.44 Very High Very High Very High
Arthritis 10 99.32 Very High Very High Very High
Dementia 2 98.64 Very High Very High Very High
Nociception 2 86.72 High High
Inflammatory Pain 2 84.56 Quite High
Mydriatic 1 78.48 Quite High
Pain 5 77.68 Quite High
Miosis 1 76.08 Quite High
Low Back Pain 4 75.56 Quite High
Lower Urinary Tract Symptoms 6 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HCNP precursor is a 21 kDa protein that binds hydrophobic ligands and Mg-ATP, and is associated with the opioid-binding protein.
HCNP precursor Binding (binds) of associated with opioid
1) Confidence 0.44 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9105667 Disease Relevance 0 Pain Relevance 0.10
BP in HK HCNP is independently attributable to physical work factors in the office, static postures, and psychological job demands, and is not primarily associated with patient lifting and transferring which are traditionally identified as risk factors for BP in hospital nursing personnel.
HK HCNP Binding (associated) of
2) Confidence 0.28 Published 2006 Journal Am. J. Ind. Med. Section Body Doc Link 16362937 Disease Relevance 0.08 Pain Relevance 0
HCNP was originally purified from the hippocampus of the young rat, and is associated with memory and learning (16).
HCNP Binding (associated) of in hippocampus associated with hippocampus
3) Confidence 0.24 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779299 Disease Relevance 0.27 Pain Relevance 0.10
These results are consistent with the hypothesis that the potentiation of the morphine-like effects of pentazocine by tripelennamine which was observed behaviorally was not due to molecular interactions at the morphine receptor.
morphine receptor Binding (interactions) of associated with fortral and morphine
4) Confidence 0.18 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6294681 Disease Relevance 0.15 Pain Relevance 1.48
PEBP was associated with memory, learning disorders, dementia [38].
PEBP Binding (associated) of associated with dementia and learning disorders
5) Confidence 0.18 Published 2003 Journal Proteome Sci Section Body Doc Link PMC165415 Disease Relevance 0.20 Pain Relevance 0.11
PEBP binds ATP, opioids and phosphatidylethanolamine and -with lower affinity-phosphatidylinositol and phosphatidylcholine.
PEBP Binding (binds) of associated with opioid
6) Confidence 0.18 Published 2003 Journal Proteome Sci Section Body Doc Link PMC165415 Disease Relevance 0 Pain Relevance 0.13
However, previous studies of the Delta(9)-THC/morphine interaction were performed using normal mice or rats and evaluated acute thermal antinociception.
morphine Binding (interaction) of associated with antinociception and morphine
7) Confidence 0.03 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17498686 Disease Relevance 0.39 Pain Relevance 0.81
The isobolographic analysis indicated a synergistic interaction between Delta(9)-THC and morphine in both the non-arthritic and the arthritic rats.
morphine Binding (interaction) of associated with arthritis and morphine
8) Confidence 0.03 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17498686 Disease Relevance 0.67 Pain Relevance 1.24
Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac.
morphine Binding (interaction) of in blood associated with diclofenac and morphine
9) Confidence 0.02 Published 2008 Journal Anal Bioanal Chem Section Title Doc Link 18418582 Disease Relevance 0 Pain Relevance 0.80
Sensitive HPLC-fluorescence detection of morphine labeled with DIB-Cl in rat brain and blood microdialysates and its application to the preliminarily study of the pharmacokinetic interaction between morphine and diclofenac.
morphine Binding (interaction) of in brain associated with diclofenac and morphine
10) Confidence 0.01 Published 2008 Journal Anal Bioanal Chem Section Title Doc Link 18418582 Disease Relevance 0 Pain Relevance 0.80
These data suggest that morphine-like mu agonists and other mu-selective and delta-selective peptide agonists in the guinea-pig ileum preparation either interact with similar opioid receptors but in a distinguishable manner or interact with different populations of opioid receptors or the peptides studied had greater intrinsic activity than the nonpeptides.
morphine-like mu Binding (interact) of in ileum associated with mu agonist, agonist, opioid receptor and morphine
11) Confidence 0.00 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3016244 Disease Relevance 0 Pain Relevance 1.05

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