INT337860

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.43
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Sf1) RNA binding (Sf1) nucleus (Sf1)
cytoplasm (Sf1)
Anatomy Link Frequency
neurons 8
Sf1 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 54 63.60 Quite High
Central nervous system 27 61.52 Quite High
Intracerebroventricular 117 34.08 Quite Low
Neuropeptide 27 23.44 Low Low
tolerance 9 9.52 Low Low
agonist 90 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
Paracetamol 9 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 27 89.88 High High
Targeted Disruption 9 88.16 High High
Obesity 54 84.84 Quite High
Hyperphagia 18 84.36 Quite High
Weight Loss 9 44.20 Quite Low
Repression 18 40.72 Quite Low
Impaired Glucose Tolerance 9 10.16 Low Low
Body Weight 54 5.00 Very Low Very Low Very Low
Diabetes Mellitus 18 5.00 Very Low Very Low Very Low
Hyperinsulinism 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By overlapping the two fluorescences, we observed that all the COUP-TFII positive neurons were also expressing the SF1 protein (overlapping green and red fluorescence) (figure 5E, yellow fluorescence).
Gene_expression (expressing) of SF1 protein in neurons
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
A large number of neurons expressing the SF1 protein were observed in the VMH (figure 5A, red fluorescence).
Gene_expression (expressing) of SF1 protein in neurons
2) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
In this paper, we report a COUP-TFII gene expression restricted to a subpopulation of neurons in the ventromedial hypothalamus expressing the SF1 protein and described as expressing the melanocortin receptor MC4-R [22], [23], [24], [25].
Gene_expression (expressing) of SF1 protein in neurons
3) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.26 Pain Relevance 0.03
We addressed the possible overlap between COUP-TFII and SF1 expression within the VMH with a double immunostaining for both proteins.
Gene_expression (expression) of SF1
4) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
Among the identified VMH markers, the nuclear receptor steroidogenic factor 1 (SF1) is expressed in a large subpopulation of neurons involved in the central control of glucose homeostasis [21], [22].
Gene_expression (expressed) of SF1 in neurons
5) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
Even so it was known that COUP-TFII mRNA and SF1 mRNA were present in the VMH, this study allowed the first identification of a subpopulation among the VMH neurons expressing both the COUP-TFII and SF1 proteins.
Gene_expression (expressing) of SF1 in neurons
6) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
On the other hand, the COUP-TFII neurons were all SF1 expressing neurons (figure 5E, yellow fluorescence).
Gene_expression (expressing) of SF1 in neurons
7) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
However, some SF1 cells were not expressing COUP-TFII (white arrows), suggesting that we had at least two distinct cellular subpopulations of SF1 neurons within the VMH, the COUP-TFII positive and the COUP-TFII negative neurons with 65% of the SF1 positive cells expressing COUP-TFII (figure 5E).
Gene_expression (neurons) of SF1 in neurons
8) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
In this paper, we described the unique and restricted localization of COUP-TFII expression to a subpopulation of VMH neurons expressing the transcription factor SF1.
Gene_expression (expressing) of factor SF1 in neurons
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.17 Pain Relevance 0.03

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