INT337865

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 0.31
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr2f2) DNA binding (Nr2f2)
Anatomy Link Frequency
pancreas 5
blood 4
neurons 4
MC3 4
hypothalamus 2
Nr2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 169 100.00 Very High Very High Very High
agonist 130 100.00 Very High Very High Very High
Central nervous system 39 94.24 High High
Neuropeptide 39 70.28 Quite High
bDMF 78 60.32 Quite High
ketamine 13 5.00 Very Low Very Low Very Low
Paracetamol 13 5.00 Very Low Very Low Very Low
tolerance 13 5.00 Very Low Very Low Very Low
antagonist 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 26 68.72 Quite High
Targeted Disruption 13 68.40 Quite High
Obesity 78 63.36 Quite High
Weight Loss 13 53.88 Quite High
Hypoglycemia 39 43.36 Quite Low
Hyperglycemia 13 40.64 Quite Low
Diabetes Mellitus 26 34.60 Quite Low
Metabolic Disorder 13 12.16 Low Low
Body Weight 78 5.00 Very Low Very Low Very Low
Hyperphagia 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COUP-TFII gene expression is modulated by the melanocortin pathway in the GT1-7 hypothalamic cell line
Regulation (modulated) of Gene_expression (expression) of COUP-TFII gene
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.05
Taken altogether, these results suggested that the changes in hypothalamic COUP-TFII expression could be centrally regulated by signals of energy supplies such as blood glucose or plasma insulin levels.
Regulation (changes) of Gene_expression (expression) of COUP-TFII in blood
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.04
Therefore, we questioned how the fed state could have such an opposite effect on COUP-TFII mRNA expression in the hypothalamus compared to the liver and the pancreas.


Regulation (effect) of Gene_expression (expression) of COUP-TFII mRNA in pancreas
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
So in vivo, an activation of the MC3/4-R could affect COUP-TFII gene expression directly through a transcriptional mechanism regardless of the peripheral effect of MTII on the other nuclei.
Regulation (affect) of Gene_expression (expression) of COUP-TFII gene in MC3
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.08
Hypothalamic COUP-TFII expression is induced by the fed state in adult mice
Regulation (Hypothalamic) of Gene_expression (expression) of COUP-TFII
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
Using a hypothalamic cell line expressing the MC4-R receptor, we have shown that its direct activation induces COUP-TFII mRNA levels in these cells, so part of the MTII effect on COUP-TFII gene expression in vivo is mediated through a direct activation of the melanocortin receptors expressed on the VMH neurons.
Regulation (effect) of Gene_expression (expression) of COUP-TFII gene in neurons
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.11
COUP-TFII being expressed on neurons known to express the MC4-R, we then checked whether an activation of this receptor could contribute to COUP-TFII expression.
Regulation (contribute) of Gene_expression (expression) of COUP-TFII in neurons
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.07 Pain Relevance 0.11
Our previous studies had shown that insulin was down-regulating COUP-TFII gene expression in liver and pancreas.
Regulation (regulating) of Gene_expression (expression) of COUP-TFII gene in pancreas
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.07
Therefore we tested the effects of intracerebroventricular (ICV) injections of the MC3/4-R agonist MTII on COUP-TFII mRNA levels in the hypothalamus.
Regulation (effects) of Gene_expression (levels) of COUP-TFII mRNA in MC3 associated with agonist and intracerebroventricular
9) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.37
Having an opposite regulation of COUP-TFII expression between these different organs could then participate in this global homeostasis.
Regulation (regulation) of Gene_expression (expression) of COUP-TFII
10) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.19 Pain Relevance 0
Taken altogether, these results suggested that the changes in hypothalamic COUP-TFII expression could be centrally regulated by signals of energy supplies such as blood glucose or plasma insulin levels.
Regulation (regulated) of Gene_expression (expression) of COUP-TFII in blood
11) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.03
As an actor of glucose homeostasis, whose expression is modulated by the nutritional status in several tissues and as it is expressed in the hypothalamus whose function is central to energy homeostasis, it was of interest to decipher the regulation of COUP-TFII expression by the nutritional status in the hypothalamus.
Regulation (regulation) of Gene_expression (expression) of COUP-TFII in hypothalamus
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.06 Pain Relevance 0
Our previous studies had shown that insulin was down-regulating COUP-TFII gene expression in liver and pancreas.
Regulation (regulating) of in liver Gene_expression (expression) of COUP-TFII gene in pancreas
13) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox