INT337872

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 0.55
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr2f2) DNA binding (Nr2f2)
Anatomy Link Frequency
liver 7
hepatocytes 6
pancreas 3
plasma 2
beta cells 2
Nr2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 169 99.18 Very High Very High Very High
agonist 130 96.16 Very High Very High Very High
Central nervous system 39 92.80 High High
Neuropeptide 39 88.72 High High
bDMF 78 66.04 Quite High
ketamine 13 5.00 Very Low Very Low Very Low
Paracetamol 13 5.00 Very Low Very Low Very Low
tolerance 13 5.00 Very Low Very Low Very Low
antagonist 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 78 92.96 High High
Hypoglycemia 39 82.56 Quite High
Repression 26 79.96 Quite High
Weight Loss 13 59.36 Quite High
Hyperglycemia 13 49.28 Quite Low
Diabetes Mellitus 26 49.12 Quite Low
Metabolic Disorder 13 47.96 Quite Low
Hyperphagia 26 33.24 Quite Low
Body Weight 78 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, an ICV MTII injection in fasting mice strongly inhibited COUP-TFII mRNA expression in the liver (figure 8B).
Negative_regulation (inhibited) of Gene_expression (expression) of COUP-TFII mRNA in liver associated with intracerebroventricular
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.11
On the other hand, the MTII injection in fasting mice significantly inhibits COUP-TFII mRNA expression in the pancreas (figure 8C).
Negative_regulation (inhibits) of Gene_expression (expression) of COUP-TFII mRNA in pancreas
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.11
We previously reported that COUP-TFII expression was reduced in the pancreas and liver of mice refed onto with a carbohydrate rich diet [7].
Negative_regulation (reduced) of Gene_expression (expression) of COUP-TFII in liver
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.08 Pain Relevance 0
The fact that heterozygous COUP-TFII gene inactivation mouse models, i.e conditional beta cells [8] or complete invalidation [10] (50% decrease in COUP-TFII expression) displayed a strong phenotype suggests that any small variations of COUP-TFII expression does lead to a disturbed physiology.
Negative_regulation (decrease) of Gene_expression (expression) of COUP-TFII in beta cells
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.09 Pain Relevance 0
Finally, we show that the fed state or intracerebroventricular injections of MTII in mice induce an increased hypothalamic COUP-TFII expression associated with a decreased hepatic and pancreatic COUP-TFII expression.


Negative_regulation (decreased) of Gene_expression (expression) of COUP-TFII associated with intracerebroventricular
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.09
This apparent opposite effect of insulin on COUP-TFII gene expression is reminiscent of the overall observation regarding peripheral vs central insulin effects on energy homeostasis.
Negative_regulation (effect) of Gene_expression (expression) of COUP-TFII gene
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.14 Pain Relevance 0.03
We addressed the possible overlap between COUP-TFII and SF1 expression within the VMH with a double immunostaining for both proteins.
Spec (possible) Negative_regulation (overlap) of Gene_expression (expression) of COUP-TFII
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
Our experiments on a hypothalamic cell line with insulin showed that this hormone was able to repress COUP-TFII mRNA expression when applied directly on the cells expressing COUP-TFII as it was observed on a pancreatic beta cell line or on cultured hepatocytes [7].
Negative_regulation (repress) of Gene_expression (expression) of COUP-TFII mRNA in hepatocytes
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.07 Pain Relevance 0.13
These results are quite intriguing since our previous data had clearly demonstrated that COUP-TFII gene expression was decreased by insulin in hepatocytes and in pancreatic ?
Negative_regulation (decreased) of Gene_expression (expression) of COUP-TFII gene in hepatocytes
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
A central activation of the melanocortin pathway represses COUP-TFII mRNA levels in the liver and in the pancreas
Negative_regulation (represses) of Gene_expression (levels) of COUP-TFII mRNA in liver
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.13
In keeping with this mechanism, we observed that in our nutritional and hormonal, eGHI and STZ mouse models, variations of circulating plasma insulin are closely associated with variation of the hypothalamic COUP-TFII mRNA levels, paralleling the modulation of POMC gene expression and therefore of the melanocortin receptor agonist (?
Negative_regulation (variation) of Gene_expression (levels) of COUP-TFII mRNA in plasma associated with agonist
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.08 Pain Relevance 0.14
Previous data from our group had clearly shown that COUP-TFII mRNA levels are inhibited in the liver and in the pancreas of fed mice and by insulin in cultured hepatocytes and in a pancreatic beta cell line [7].
Negative_regulation (inhibited) of Gene_expression (levels) of COUP-TFII mRNA in hepatocytes
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.12
We previously reported that COUP-TFII expression was reduced in the pancreas and liver of mice refed onto with a carbohydrate rich diet [7].
Negative_regulation (reduced) of in pancreas Gene_expression (expression) of COUP-TFII in liver
13) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox