INT337876

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.18
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr2f2) DNA binding (Nr2f2)
Anatomy Link Frequency
hypothalamus 3
Nr2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 117 99.04 Very High Very High Very High
bDMF 54 88.52 High High
agonist 90 83.88 Quite High
Neuropeptide 27 60.64 Quite High
Central nervous system 27 23.88 Low Low
ketamine 9 5.00 Very Low Very Low Very Low
Paracetamol 9 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 18 64.88 Quite High
Obesity 54 52.16 Quite High
Diabetes Mellitus 18 33.44 Quite Low
Hyperglycemia 9 21.76 Low Low
Metabolic Disorder 9 7.16 Low Low
Body Weight 54 5.00 Very Low Very Low Very Low
Hypoglycemia 27 5.00 Very Low Very Low Very Low
Hyperphagia 18 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 9 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From our previous studies on COUP-TFII mRNA regulation in liver and pancreas, we looked at the regulation of COUP-TFII mRNA levels in the hypothalamus of C57bl/6J adult mice according to their nutritional status.
Regulation (regulation) of COUP-TFII mRNA in hypothalamus
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.03
From our previous studies on COUP-TFII mRNA regulation in liver and pancreas, we looked at the regulation of COUP-TFII mRNA levels in the hypothalamus of C57bl/6J adult mice according to their nutritional status.
Regulation (regulation) of COUP-TFII mRNA in hypothalamus
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
To confirm this hypothesis, we investigated the effects of glucose and/or insulin in the control of hypothalamic COUP-TFII mRNA levels.
Spec (investigated) Regulation (control) of COUP-TFII mRNA
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.03
On the other hand, the MTII-injected fasting mice displayed significantly higher COUP-TFII mRNA levels than the control fasting mice injected with CSF (figure 7C).
Regulation (control) of COUP-TFII mRNA
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.33
Following this observation, we asked whether cAMP had a direct transcriptional effect on the COUP-TFII gene promoter in an hypothalamic cell line.
Spec (whether) Regulation (effect) of COUP-TFII gene promoter
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.06 Pain Relevance 0.10
As insulin and glycemia are so tightly linked, in order to distinguish between the relative implication of glucose or insulin on hypothalamic COUP-TFII regulation, we used the euglycemic/hyperinsulinemic (eGHI) clamp technique to impose high circulating insulin while maintaining euglycemia with an intra-jugular glucose infusion (figure 2A).
Regulation (regulation) of COUP-TFII
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.03
In this paper, we report 1) a differential regulation of COUP-TFII mRNA levels by the nutritional status with an induction of its expression in the hypothalamus in the fed state 2) COUP-TFII protein expression in a subpopulation of ventromedial hypothalamic neurons 3) COUP-TFII expression in the hypothalamus and in a hypothalamic cell line being controlled by the melanocortin pathway leading to a direct COUP-TFII transcriptional activation.


Regulation (regulation) of COUP-TFII mRNA in hypothalamus
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.05 Pain Relevance 0
To demonstrate the direct implication of cAMP in the control of the COUP-TFII gene promoter, the GT1-7 cells were transiently transfected with a reporter plasmid carrying the luciferase gene controlled by the 328 bp 5?
Regulation (control) of COUP-TFII gene promoter
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.06 Pain Relevance 0.07
Under these experimental conditions, a higher expression of COUP-TFII mRNA in the fed mice than in the fasted mice was observed, therefore the ICV per se did not disturb the previously observed COUP-TFII mRNA regulation by the nutritional status (figure 7C).
Neg (not) Regulation (regulation) of COUP-TFII mRNA associated with intracerebroventricular
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.36

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