INT337884

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.08
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) nucleus (Nr2f2)
DNA binding (Nr2f2) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)
Anatomy Link Frequency
pancreas 6
hepatocytes 4
liver 2
Ins1 (Mus musculus)
Nr2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 60 79.48 Quite High
Central nervous system 18 9.00 Low Low
Intracerebroventricular 78 5.00 Very Low Very Low Very Low
bDMF 36 5.00 Very Low Very Low Very Low
Neuropeptide 18 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 36 77.04 Quite High
Hyperglycemia 6 49.28 Quite Low
Hypoglycemia 18 43.36 Quite Low
Diabetes Mellitus 12 43.24 Quite Low
Metabolic Disorder 6 32.04 Quite Low
Weight Loss 6 20.16 Low Low
Body Weight 36 5.00 Very Low Very Low Very Low
Repression 12 5.00 Very Low Very Low Very Low
Hyperphagia 12 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are quite intriguing since our previous data had clearly demonstrated that COUP-TFII gene expression was decreased by insulin in hepatocytes and in pancreatic ?
insulin Negative_regulation (decreased) of Gene_expression (expression) of COUP-TFII gene in hepatocytes
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
Our previous studies had shown that insulin was down-regulating COUP-TFII gene expression in liver and pancreas.
insulin Negative_regulation (regulating) of Gene_expression (expression) of COUP-TFII gene in pancreas
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.07
Our previous studies had shown that insulin was down-regulating COUP-TFII gene expression in liver and pancreas.
insulin Negative_regulation (down) of Gene_expression (expression) of COUP-TFII gene in pancreas
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.07
In fact, COUP-TFII gene expression is decreased by secreted insulin in response to glucose in pancreatic beta cells and by insulin and glucose in hepatocytes [7].
insulin Negative_regulation (decreased) of Gene_expression (expression) of COUP-TFII gene in hepatocytes
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.08 Pain Relevance 0
Our previous studies had shown that insulin was down-regulating COUP-TFII gene expression in liver and pancreas.
insulin Negative_regulation (regulating) of in liver Gene_expression (expression) of COUP-TFII gene in pancreas
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.07
Our previous studies had shown that insulin was down-regulating COUP-TFII gene expression in liver and pancreas.
insulin Negative_regulation (down) of in liver Gene_expression (expression) of COUP-TFII gene in pancreas
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.07

General Comments

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