INT337885

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.27
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) nucleus (Nr2f2)
DNA binding (Nr2f2) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)
Anatomy Link Frequency
hypothalamus 4
Ins1 (Mus musculus)
Nr2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 9 27.44 Quite Low
Intracerebroventricular 39 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
bDMF 18 5.00 Very Low Very Low Very Low
Central nervous system 9 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 6 87.52 High High
Hyperglycemia 3 75.84 Quite High
Body Weight 18 5.00 Very Low Very Low Very Low
Obesity 18 5.00 Very Low Very Low Very Low
Hypoglycemia 9 5.00 Very Low Very Low Very Low
Repression 6 5.00 Very Low Very Low Very Low
Hyperphagia 6 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Weight Loss 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to decipher the mechanisms by which insulin is able to stimulate hypothalamic COUP-TFII gene expression, we needed to identify precisely the nuclei expressing this transcription factor.
insulin Positive_regulation (stimulate) of Gene_expression (expression) of COUP-TFII gene
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0
Thus, insulin per se was able to induce COUP-TFII mRNA levels in the hypothalamus independently of glucose.
insulin Positive_regulation (induce) of Gene_expression (levels) of COUP-TFII mRNA in hypothalamus
2) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.16 Pain Relevance 0
Taken all together, these results showed that insulin is able to induce a rapid increase in hypothalamus COUP-TFII gene expression.
insulin Positive_regulation (induce) of Gene_expression (expression) of COUP-TFII gene in hypothalamus
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.11 Pain Relevance 0

General Comments

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