INT337894

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) nucleus (Nr2f2)
DNA binding (Nr2f2) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)
Anatomy Link Frequency
MC3 2
Ins1 (Mus musculus)
Nr2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 20 100.00 Very High Very High Very High
Central nervous system 6 73.76 Quite High
Intracerebroventricular 26 5.00 Very Low Very Low Very Low
bDMF 12 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 6 82.56 Quite High
Repression 4 77.92 Quite High
Weight Loss 2 59.36 Quite High
Body Weight 12 5.00 Very Low Very Low Very Low
Obesity 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Hyperphagia 4 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This apparent opposite effect of insulin on COUP-TFII gene expression is reminiscent of the overall observation regarding peripheral vs central insulin effects on energy homeostasis.
insulin Regulation (effect) of Gene_expression (expression) of COUP-TFII gene
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.14 Pain Relevance 0.03
We therefore investigated the effect of insulin or of a MC3/4-R agonist on hypothalamic COUP-TFII gene expression in a hypothalamic mouse cell line, the GT1-7 cells, known to express the insulin receptor, the COUP-TFII protein (data not shown) as well as the MC4-R receptor [29].First, the cells were cultured for 18 hours with 100 nM insulin.
insulin Spec (investigated) Regulation (effect) of Gene_expression (expression) of COUP-TFII gene in MC3 associated with agonist
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.08 Pain Relevance 0.12

General Comments

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