INT337896

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) nucleus (Nr2f2)
DNA binding (Nr2f2) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)
Anatomy Link Frequency
hepatocytes 1
Ins1 (Mus musculus)
Nr2f2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 20 87.28 High High
Intracerebroventricular 26 70.92 Quite High
bDMF 12 61.36 Quite High
Central nervous system 6 59.40 Quite High
Neuropeptide 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 100.00 Very High Very High Very High
Body Weight 12 5.00 Very Low Very Low Very Low
Obesity 12 5.00 Very Low Very Low Very Low
Hypoglycemia 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Hyperphagia 4 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under these conditions, we observed a strong repression of COUP-TFII mRNA levels by insulin in cells directly exposed to insulin (figure 6A).
insulin Negative_regulation (repression) of COUP-TFII mRNA associated with repression
1) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0.10 Pain Relevance 0.15
Previous data from our group had clearly shown that COUP-TFII mRNA levels are inhibited in the liver and in the pancreas of fed mice and by insulin in cultured hepatocytes and in a pancreatic beta cell line [7].
insulin Negative_regulation (inhibited) of COUP-TFII mRNA in hepatocytes
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.12

General Comments

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