INT337915

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0

protein complex (Tgfbr1, Smad2) cell differentiation (Tgfbr1) intracellular (Smad2) embryo development (Tgfbr1) cytoplasm (Smad2) signal transduction (Tgfbr1)

Tgfbr1 (Mus musculus) Smad2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 4 5.00 anesthesia 2 5.00 cytokine 1 5.00 ketamine 1 5.00 dexamethasone 1 5.00 Inflammatory response 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Blister 31 78.24 Toxicity 3 76.48 Keloid Scars 18 37.80 Glaucoma 6 29.68 Cicatrix 1 22.12 Injury 2 10.40 Death 2 5.84 Ocular Hypertension 17 5.00 INFLAMMATION 4 5.00 Infection 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In experiments described herein, the ALK-5 inhibitor SB-505124 induced a marked reduction in levels of phosphorylated Smad2 (pSmad2) and downstream proteins of TGF-?

ALK-5 Positive_regulation (induced) of Negative_regulation (reduction) of Smad2

1) Confidence 0.05 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.