INT337917

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.06 Pain Relevance 0

cell differentiation (Tgfbr1) signal transduction (Tgfbr1) cell motility (Tgfbr1) plasma membrane (Tgfbr1) embryo development (Tgfbr1) protein complex (Tgfbr1)

sb (Mus musculus) Tgfbr1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 16 5.00 anesthesia 8 5.00 cytokine 4 5.00 ketamine 4 5.00 dexamethasone 4 5.00 Inflammatory response 4 5.00 imagery 4 5.00

Disease Link Frequency Relevance Heat Toxicity 12 97.20 Blister 124 96.16 Infection 16 95.08 Keloid Scars 72 53.24 Parainfluenza Virus Infection 4 21.84 Ocular Hypertension 68 12.64 Glaucoma 24 11.36 INFLAMMATION 16 5.00 Fibrosis 8 5.00 Death 8 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To explore the interaction or binding of SB-505124 with ALK-5, we docked SB-505124 into the ATP/ligand binding pocket of ALK-5 (Protein data bank access code 1VJY) [45].

SB-505124 Binding (binding) of ALK-5

1) Confidence 0.00 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.28 Pain Relevance 0

To explore the interaction or binding of SB-505124 with ALK-5, we docked SB-505124 into the ATP/ligand binding pocket of ALK-5 (Protein data bank access code 1VJY) [45].

SB-505124 Binding (interaction) of ALK-5

2) Confidence 0.00 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.29 Pain Relevance 0

Interaction between SB-505124 and ALK-5

SB-505124 Binding (Interaction) of ALK-5

3) Confidence 0.00 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.30 Pain Relevance 0

The interaction between SB-505124 and the kinase ALK-5 was investigated using computational docking software.

SB-505124 Binding (interaction) of ALK-5

4) Confidence 0.00 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956700 Disease Relevance 0.19 Pain Relevance 0

General Comments

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