INT338019

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (AR) transport (AR) enzyme binding (AR)
DNA binding (AR) cell-cell signaling (AR) cytoplasm (AR)
Egf (Mus musculus)
AR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 52.40 Quite High
agonist 1 47.20 Quite Low
member 8 2 5.00 Very Low Very Low Very Low
monoamine 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 1 93.48 High High
Reprotox - General 1 94 91.86 High High
Death 7 76.88 Quite High
Disease 6 67.60 Quite High
Recurrence 4 63.68 Quite High
Pain 1 52.40 Quite High
Cancer 14 51.76 Quite High
Metastasis 5 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanisms of progression to CRPC that involve or utilize the androgen signaling pathway include: hypersensitivity due to AR gene amplification [5,6]; changes in AR co-regulators such as nuclear receptor coactivators (NCOA1 and NCOA2) [7,8]; intraprostatic de novo synthesis of androgen[9] or metabolism of AR ligands from residual adrenal androgens[10,11]; AR promiscuity of ligand specificity due to mutations[12]; and ligand-independent activation of AR by growth factors [protein kinase A (PKA), interleukin 6 (IL6), and epidermal growth factor (EGF)][13-15].
epidermal growth factor Positive_regulation (activation) of AR associated with hypersensitivity and reprotox - general 1
1) Confidence 0.07 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2956710 Disease Relevance 1.02 Pain Relevance 0.05

General Comments

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