INT33803

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Context Info
Confidence 0.50
First Reported 1986
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.09
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgds) transport (Ptgds) nuclear envelope (Ptgds)
extracellular space (Ptgds) extracellular region (Ptgds) Golgi apparatus (Ptgds)
Anatomy Link Frequency
PGE2 1
Ptgds (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 4 100.00 Very High Very High Very High
narcan 2 99.84 Very High Very High Very High
antagonist 3 99.72 Very High Very High Very High
Endogenous opioid 1 97.68 Very High Very High Very High
Antinociceptive 4 94.52 High High
Chronic pancreatitis 6 90.64 High High
Intracerebroventricular 1 79.24 Quite High
Inflammation 5 78.44 Quite High
Central nervous system 1 56.80 Quite High
medulla 1 27.92 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 11 96.56 Very High Very High Very High
Nociception 1 83.84 Quite High
INFLAMMATION 6 78.44 Quite High
Stress Incontinence 3 75.92 Quite High
Obesity 19 74.60 Quite High
Cancer 2 14.36 Low Low
Pain 1 13.12 Low Low
Reprotox - General 3 3 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Breast Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antinociceptive action of centrally-administered PGD2 was markedly attenuated after pretreatment of the rats with 5,6-dihydroxytryptamine, a selective neurotoxin for central serotonergic neurones, and p-chlorophenylalanine, a specific inhibitor of serotonin synthesis, indicating that the PGD2 action is serotonin-mediated.
Positive_regulation (serotonin-mediated) of PGD2 associated with serotonin and antinociceptive
1) Confidence 0.50 Published 1986 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3016786 Disease Relevance 0.08 Pain Relevance 0.65
However, low concentrations were found in males with all ranges of fertility, suggesting that the function of PGDS either is not necessary for male fertility or can be assumed by other proteins when its concentration is low.
Neg (not) Positive_regulation (necessary) of PGDS
2) Confidence 0.41 Published 2002 Journal Biol. Reprod. Section Abstract Doc Link 11804963 Disease Relevance 0 Pain Relevance 0
BN52021, a PAF antagonist, reduced the accumulation of pancreatic TXB2, 6-keto PGF1 alpha, and PGD2, and did not affect PGE2.
Positive_regulation (accumulation) of PGD2 in PGE2 associated with antagonist
3) Confidence 0.16 Published 1994 Journal J. Surg. Res. Section Abstract Doc Link 8277767 Disease Relevance 0.79 Pain Relevance 0.45
could induce enzymatic conversion of prostaglandin D2 (PGD2) and the endogenous
Positive_regulation (induce) of PGD2
4) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.21 Pain Relevance 0

General Comments

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