INT338033

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.62
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) plasma membrane (F2r) signal transducer activity (F2r)
Anatomy Link Frequency
sensory neurons 1
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 60 99.38 Very High Very High Very High
Inflammation 36 97.24 Very High Very High Very High
imagery 21 94.96 High High
agonist 42 90.48 High High
Analgesic 6 89.76 High High
nociceptor 48 88.88 High High
Inflammatory mediators 9 85.88 High High
qutenza 42 83.84 Quite High
Antinociceptive 12 83.44 Quite High
neuropeptide release 6 73.48 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 97.24 Very High Very High Very High
Pressure And Volume Under Development 3 94.80 High High
Nervous System Injury 3 81.16 Quite High
Increased Venous Pressure Under Development 3 75.72 Quite High
Injury 9 66.84 Quite High
Coagulation Disorder 6 64.96 Quite High
Nociception 63 50.96 Quite High
Targeted Disruption 9 48.00 Quite Low
Pain 18 43.52 Quite Low
Sprains And Strains 3 6.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The basal CGRP release was unaffected by the presence of PAR1-AP.
Localization (presence) of PAR1 associated with calcitonin gene-related peptide
1) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.05 Pain Relevance 0.52
We next tested sensitization of TRPV1 by thrombin in wild-type and PAR1-/- mice.
Localization (sensitization) of PAR1
2) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.09 Pain Relevance 0.39
To the best of our knowledge no studies have investigated the localization of functional PAR1, 3 and 4 receptors in sensory neurons, nor the role of receptors activated by thrombin in TRPV1 sensitisation or in activation of PKC?
Spec (investigated) Localization (localization) of PAR1 in sensory neurons
3) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.48 Pain Relevance 0.29

General Comments

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