INT338053

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.47
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Calca) cytoplasm (Calca) signal transducer activity (F2r)
signal transduction (F2r) extracellular space (Calca) extracellular region (Calca)
Anatomy Link Frequency
nerve 2
F2r (Mus musculus)
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 40 100.00 Very High Very High Very High
Neuropeptide 24 100.00 Very High Very High Very High
nociceptor 32 99.88 Very High Very High Very High
Nerve growth factor 28 98.56 Very High Very High Very High
unmyelinated 6 95.76 Very High Very High Very High
neuropeptide release 4 89.04 High High
cOX1 2 80.04 Quite High
c fibre 2 73.80 Quite High
qutenza 28 58.72 Quite High
substance P 10 54.60 Quite High
Disease Link Frequency Relevance Heat
Nociception 42 96.08 Very High Very High Very High
Hyperalgesia 6 50.24 Quite High
Pain 12 49.56 Quite Low
Coagulation Disorder 4 47.64 Quite Low
INFLAMMATION 26 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 4 5.00 Very Low Very Low Very Low
Rupture 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Release of CGRP by heat is potentiated by PAR1
PAR1 Positive_regulation (potentiated) of Localization (Release) of CGRP associated with calcitonin gene-related peptide
1) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.17 Pain Relevance 0.88
In a skin-nerve preparation the release of the neuropeptide CGRP by heat was potentiated by PAR1-AP.
PAR1 Positive_regulation (potentiated) of Localization (release) of CGRP in nerve associated with neuropeptide
2) Confidence 0.05 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2956715 Disease Relevance 0.30 Pain Relevance 0.27

General Comments

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