INT338057

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Calca) cytoplasm (Calca) signal transducer activity (F2r)
signal transduction (F2r) extracellular space (Calca) extracellular region (Calca)
Anatomy Link Frequency
nociceptor 3
F2r (Mus musculus)
Calca (Mus musculus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
nociceptor 16 99.38 Very High Very High Very High
Kinase C 1 82.12 Quite High
Inflammation 12 74.72 Quite High
qutenza 14 74.32 Quite High
Neuropeptide 12 72.88 Quite High
Hyperalgesia 3 70.96 Quite High
Nerve growth factor 14 54.96 Quite High
substance P 5 51.36 Quite High
unmyelinated 3 22.40 Low Low
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 2 75.60 Quite High
Hyperalgesia 3 70.96 Quite High
Nociception 21 69.28 Quite High
INFLAMMATION 13 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Coagulation Disorder 2 5.00 Very Low Very Low Very Low
Rupture 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sensitization of TRPV1 by thrombin, together with the observation that CGRP is expressed in the thrombin-responsive nociceptor population, suggests that the CGRP release activated by heat should be enhanced by PAR1 activation.
Positive_regulation (activation) of PAR1 in nociceptor Positive_regulation (enhanced) of Localization (release) of CGRP in nociceptor associated with nociceptor and calcitonin gene-related peptide
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.28 Pain Relevance 0.71

General Comments

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