INT338059

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2r) extracellular region (Nrtn) plasma membrane (F2r)
signal transducer activity (F2r)
Anatomy Link Frequency
neuronal 2
Nrtn (Mus musculus)
F2r (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 14 98.20 Very High Very High Very High
Inflammation 12 90.16 High High
Antinociceptive 4 78.88 Quite High
Pain 6 74.08 Quite High
Analgesic 2 45.76 Quite Low
imagery 7 35.64 Quite Low
Neuropeptide 12 32.80 Quite Low
agonist 14 23.04 Low Low
Calcitonin gene-related peptide 20 5.00 Very Low Very Low Very Low
nociceptor 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 90.16 High High
Nociception 21 84.80 Quite High
Pain 6 74.08 Quite High
Injury 3 21.44 Low Low
Rupture 2 20.56 Low Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Coagulation Disorder 2 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results are consistent with an action of the two neurotrophins on separate neuronal populations, however, because NGF does not increase the few IB4+ neurones which respond to thrombin, while NTN does increase the number of these IB4+ neurons, consistent with the idea that NGF unregulates the number of PAR1/4 expressing neurons in the peptidergic population, while NTN induces de novo expression of PAR1/4 receptors in the IB4+ neuronal population.


NTN Positive_regulation (induces) of Gene_expression (expression) of PAR1 in neuronal associated with nerve growth factor
1) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2956715 Disease Relevance 0.45 Pain Relevance 0.41

General Comments

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