INT338098

Context Info Confidence 0.57 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.16 Pain Relevance 0

Anatomy Mention Frequency thyroid 1

Pain Term Frequency Confidence Heat COX2 1 18.40 COX-2 inhibitor 1 14.72 palliative 1 5.00 withdrawal 8 5.00 Inflammation 1 5.00 Pain 2 5.00 Neuropeptide 1 5.00 imagery 4 5.00 Catecholamine 1 5.00

Disease Term Frequency Confidence Heat Thyroid Neoplasm 169 96.44 Disease 81 89.92 Disease Progression 1 86.00 Liver Failure 1 85.80 Toxicity 2 83.12 Diarrhoea 3 64.32 Hypertension 1 63.28 Exanthema 2 54.08 Hepatocellular Cancer 1 52.04 Renal Cancer 1 50.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

AMG-706 Finally, in a third abstract reported at the 2007 annual meeting of the American Society of Clinical Oncology, AMG-706, another multikinase inhibitor (VEGF/PDGF receptors, Kit and RET), was studied in a phase II trial of patients with advanced differentiated thyroid cancer or medullary thyroid cancer.

Negative_regulation (inhibitor) of PDGF receptors in thyroid associated with thyroid neoplasm

1) Confidence 0.57 Published 2010 Journal Journal of Thyroid Research Section Body Doc Link PMC2956973 Disease Relevance 1.16 Pain Relevance 0

General Comments

This test has worked.