INT33810

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Context Info
Confidence 0.55
First Reported 1986
Last Reported 2009
Negated 1
Speculated 3
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 3.99
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
adipocyte 3
skeletal muscle 2
muscle 1
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 38 100.00 Very High Very High Very High
Clonidine 1 86.68 High High
noradrenaline 42 37.84 Quite Low
agonist 31 31.84 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 958 99.48 Very High Very High Very High
Diabetes Mellitus 13 70.52 Quite High
Insulin Resistance 15 59.40 Quite High
Hyperinsulinism 5 58.44 Quite High
Rheumatoid Arthritis 25 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Weight Loss 5 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discrepancy between mRNA and proteins suggests once again that post-transcriptional regulation of perilipin and HSL occurred in adipocytes.
Regulation (regulation) of HSL in adipocytes associated with obesity
1) Confidence 0.55 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 1.02 Pain Relevance 0.04
Depot difference in the HSL distribution could therefore influence HSL regulation and modulate TAG accumulation.
Regulation (regulation) of HSL
2) Confidence 0.48 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.50 Pain Relevance 0.04
HSL Ser563, Ser659, and Ser660 are major PKA phosphorylation sites, although Ser563 may not affect HSL activity directly (14).
Neg (not) Spec (may) Regulation (affect) of HSL
3) Confidence 0.40 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.23 Pain Relevance 0.12
HSL activity appears to be regulated by site-specific phosphorylation on several serine residues.
Spec (appears) Regulation (regulated) of HSL
4) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.47 Pain Relevance 0.11
A previous study in men and women during exercise has shown that muscle Ser659 phosphorylation and muscle HSL activity show a very similar pattern with respect to exercise response and dependency on sex, indicating that Ser659 serves an important role in the regulation of HSL activity in human skeletal muscle (13), as has been demonstrated in adipocytes (14).
Regulation (regulation) of HSL in skeletal muscle associated with obesity
5) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.35 Pain Relevance 0
On the other hand, HSL Ser563 and Ser565 phosphorylation have been suggested not to be major regulators of HSL activity in human skeletal muscle (11,13).
Regulation (regulators) of HSL in skeletal muscle
6) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.59 Pain Relevance 0
The absence of correlation between protein expression and mRNA level suggests that HSL may be regulated at some post-transcriptional levels (such as phosphorylation which activates HSL activity and induces HSL translocation from the cytosol to the lipid droplet upon adipocyte stimulation [3]).
Spec (may) Regulation (regulated) of HSL in adipocyte
7) Confidence 0.24 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.61 Pain Relevance 0.03
The effect of interleukin-1 and interleukin-2 on the adrenergic control of hormone-sensitive lipase in the human adipocyte.
Regulation (control) of hormone-sensitive lipase in adipocyte
8) Confidence 0.21 Published 1986 Journal Surgery Section Title Doc Link 3016934 Disease Relevance 0.09 Pain Relevance 0.09
It is still unclear which of the PKA phosphorylation sites on HSL are important in mediating the effect of catecholamines on in vivo muscle HSL activity.
Regulation (effect) of HSL in muscle associated with catecholamine
9) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.12 Pain Relevance 0.12

General Comments

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